Wyniki badań naukowców z University of Michigan wskazują, że terapia skierowana przeciwko białku IFN-kappa może być skuteczna w łagodzeniu objawów łuszczycy. Odkrycie to może doprowadzić do opracowania efektywnej metody leczenia tej choroby.
Amerykańscy naukowcy odkryli, że podwyższenie poziomu interferonu kappa ma wpływ na nasilenie stanu zapalnego i zwiększenie produkcji cytokin w przebiegu łuszczycy. Wyniki badań zostały opublikowane w czasopiśmie naukowym „Journal of Investigative Dermatology”.
Potencjalna metoda leczenia łuszczycy
Interferon kappa to białko produkowane przez komórki skóry. Odgrywa ważną rolę w kształtowaniu odpowiedzi immunologicznej na działanie wirusów. W zmianach skórnych u pacjentów z łuszczycą zostały wykryte nietypowo wysokie poziomy cząsteczek interferonu kappa.
Jak wyjaśnia prof. Michelle Kahlenberg, ekspertka w dziedzinie reumatologii i jedna z głównych autorek projektu, najnowsze badania pozwoliły lepiej zrozumieć wpływ interferonu na przebieg łuszczycy:
– Było wiadomo, że łuszczycowe stany zapalne mają związek z ekspresją genu związanego z interferonem. Nie wiedzieliśmy jednak do tej pory, w jaki sposób interferon wpływa na zaostrzenie choroby. Zrozumienie, jak interferon kappa moduluje przebieg łuszczycy, przybliża nas do optymalizacji terapii.
Badania na myszach
W badaniach na modelach mysich naukowcy wyodrębnili trzy grupy badawcze. W grupie pierwszej u zwierząt utrzymywano interferon kappa na niskim poziomie, w grupie drugiej poziom białka był w normie, natomiast w ostatniej – podwyższony ponad normę. Analiza wykazała, że podwyższony poziom białka wywołał reakcję zapalną prowadzącą do zmian skórnych.
Jak zwraca uwagę dr Mehrnaz Gharaee-Kermani, jeden z głównych autorów projektu:
– Wyniki naszych badań pokazują, w jaki sposób mikrobiota skórna może wpływać na kształtowanie reakcji zapalnej. Interesuje nas, w jaki sposób ta wiedza przełoży się na praktykę kliniczną.
Autorzy badań podkreślają, że uzyskane wyniki pozwolą na stworzenie terapii dostosowanych do indywidualnych przypadków na podstawie pomiaru poziomu interferonu. Może to pozwolić na efektywniejsze leczenie łuszczycy. Badacze kontynuują obecnie badania nad rolą interferonu kappa u pacjentów cierpiących na łuszczycę. Projekt jest finansowany przez amerykańską organizację National Psoriasis Foundation.
Źródło: sciencedaily.com
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