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Biomateriał wspiera regenerację uszkodzonych ścięgien

Ten tekst przeczytasz w 2 min.

Inspirując się właściwościami śluzu ślimaka w regeneracji skóry, naukowcy z USA stworzyli materiał, który stymuluje proces gojenia się urazów ścięgien. Opatrunek działa dwukierunkowo – łączy uszkodzone tkanki i zabezpiecza ścięgna podczas ruchu. Wynalazek może również posłużyć jako przekaźnik leków.

Urazy ścięgien najczęściej są konsekwencją aktywności fizycznej lub procesu starzenia się. Niejednokrotnie są one bolesne i znacznie ograniczają sprawność fizyczną. Gojenie takiego uszkodzenia jest z kolei procesem długotrwałym, a pomimo postępu chirurgii i regularnej rehabilitacji, ścięgno rzadko uzyskuje integralność i regeneruje się do stanu sprzed urazu. Eksperci zauważają, że istnieje niezaspokojona potrzeba na skuteczniejsze terapie w tym zakresie.

Nieinwazyjna regeneracja ścięgien

Zespół naukowców z Wyss Institute w Stanach Zjednoczonych opracował dwustronny materiał oparty o adhezyjny hydrożel o nazwie Janus Tough Adhesive (JTA). Biomateriał działa dwukierunkowo. Jedna z jego powierzchni zawiera chitozan (organiczny związek chemiczny z grupy polisacharydów), który mocno wiąże się ze ścięgnami i łączy uszkodzone tkanki, tym samym wspomagając proces gojenia. Druga powierzchnia to zwykły hydrożel, który osłania ścięgno przed kontaktem z innymi tkankami i zabezpiecza je podczas ruchu.

Wynalazek amerykańskich naukowców został przetestowany na ludzkich oraz zwierzęcych komórkach. Badacze wykazali, że na wyizolowanych świńskich ścięgnach, wciąż pokrytych krwią, żel wiązał się silniej w porównaniu ze standardowymi klejami tkankowymi stosowanymi w chirurgii. Materiał wszczepiono również do ścięgien rzepki i ścięgien Achillesa u szczurów. Również w tym przypadku zaobserwowano skuteczne działanie materiału, który pozwolił na nieinwazyjną regenerację. Dr Benjamin Freedman, główny autor badań, podkreślił, że JTA u szczurów pozostawało na swoim miejscu w ciągu trzytygodniowej implantacji, a także znacznie ułatwiło gojenie się ścięgien. O 25 proc. zmniejszyło się również powstawanie blizn w porównaniu z chirurgicznie naprawianymi ścięgnami.

Źródło: Wyss Institute

Możliwość aplikowania leków do uszkodzonego ścięgna

Naukowcy, badając zastosowania JTA na ścięgnach szczurów, sprawdzili również, czy materiał może skutecznie służyć jako przekaźnik leków. W tym celu w strukturę wynalazku zaaplikowano kortykosteroid, lek przeciwzapalny. Związek powoli, w sposób ciągły, uwalniał się do uszkodzonego ścięgna. Eksperci wykazali, że rozwiązanie znacznie przyspieszyło zwalczenie stanu zapalnego. Dr Michaela Kneissel, autorka badania, zauważyła, że połączenie JTA z możliwością aplikowania leków jest obiecującą drogą do opracowania skutecznej terapii regeneracji uszkodzonych ścięgien.

Naukowcy podkreślają, że ich wynalazek jest całkowicie bezpieczny oraz biokompatybilny. Wykorzystany w produkcie chitozan pozyskiwany jest z muszli skorupiaków. Wszystkie składniki JTA są już także powszechnie stosowane w medycynie. Dr David Mooney, który kierował badaniami, wskazuje, że rozwiązanie może wspierać regenerację wielu urazów ścięgien, a także pozwolić pacjentom na odzyskanie pełnej mobilności i funkcji ścięgien.

Źródło: wyss.harvard.edu

 

 

Przeczytaj także:

Najczęstsze urazy ścięgna

Biblioteka Faktów

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Chirurgia Plastyczna i Oparzenia”:

Wykorzystanie opatrunków hydrożelowych w leczeniu wojennych ran oparzeniowych

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