Mechanizm antybakteryjnego działania srebra nie był do tej pory dokładnie poznany przez naukę. Dzięki badaniom przeprowadzonym przez naukowców z University of Arkansas może się to zmienić.
Ważne odkrycie
Badania przeprowadzone przez naukowców z University of Arkansas pozwoliły przybliżyć specyfikę procesu niszczenia bakterii przez jony srebra. Dzięki zastosowaniu nowatorskiej metodologii polegającej na badaniu pojedynczych białek w żywych komórkach bakterii badacze mogą lepiej zrozumieć reakcję bakterii na działanie nanocząstek srebra. Odkrycie to pozwoli opracować skuteczniejsze środki lecznicze oparte na srebrze, dzięki czemu może się stać istotnym narzędziem w walce z wielolekoopornymi drobnoustrojami (tzw. superbakterie).
Zaskakujące wnioski
Testy wykonane przez naukowców z University of Arkansas doprowadziły do zaskakujących odkryć. Badacze obserwowali i analizowali specyficzne białka znajdujące się w żywych komórkach bakterii Escherichia coli. Badając reakcję tych białek na kontakt z cząsteczkami srebra, przekonali się, że wbrew oczekiwaniom srebro przyspieszyło dynamikę białek, zamiast ją spowolnić.
Naukowcy zaobserwowali, że jony srebra doprowadzały do separacji włókien DNA w komórkach bakterii i osłabiały połączenia pomiędzy białkami a DNA. Odłączone od molekuł DNA białka poruszają się znacznie szybciej.
Nowatorska metodologia
Zespół naukowców z University of Arkansas wykorzystał do badania właściwości srebra nowatorską, niestosowaną dotychczas do tego celu metodę. Kierujący badaniami profesor Yong Wang i jego współpracownicy oparli badania nad srebrem na fotoaktywowanej mikroskopii lokalizacyjnej (ang. single-particle tracking photoactivated microscopy). Jest to zaawansowana technika obrazowania, za pomocą której możliwe jest śledzenie pojedynczych cząsteczek.
Nowatorskość badań polegała na tym, że dotychczas mechanizmy oddziaływania jonów srebra na bakterie były badane z użyciem testów biologicznych, za pomocą których porównuje się stan organizmu poddanego działaniu substancji aktywnej ze stanem organizmu nieeksponowanego na tę substancję. Metoda wykazuje skuteczność, ale pozwala jedynie na uchwycenie „migawek”, a nie całego procesu. Zastosowanie fotoaktywowanej mikroskopii lokalizacyjnej pozwoliło na zbadanie właściwości bakteriobójczych srebra pod zupełnie nowym kątem.
Źródło: http://nauka.pap.pl/, https://news.uark.edu/
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