Naukowcy z dwóch amerykańskich ośrodków opracowali płynny bandaż, który wskazuje, jaka ilość tlenu dociera do przeszczepionej tkanki. Jak wskazują badania, wynalazek amerykańskich naukowców może być skuteczniejszy niż stosowane dotychczas w leczeniu ran przewodowe oksymetry tkankowe.
Zespół badaczy z Massachusetts General Hospital oraz chirurgów z Beth Israel Deaconess Medical Center (BIDMC) potwierdził w badaniach klinicznych na ludziach skuteczność plastycznego bandaża, który mierzy stężenie tlenu w przeszczepionej tkance. Wyniki badań opublikowano w czasopiśmie naukowym „Science Advances”.
Nowa technologia
Opracowany przez zespół amerykańskich naukowców bandaż zawiera fosforyzujące substancje, które świecą na czerwono lub zielono w zależności od poziomu utlenienia tkanki. Początkowo do uzyskania tego efektu wykorzystywano błysk aparatu, który pobudzał zawarte w bandażu substancje. W późniejszej fazie projektu badacze zaimplementowali do bandaża zasilaną bateryjnie głowicę czujnika, co wyeliminowało potrzebę zastosowania aparatu. Finalny produkt to samodzielny, wysoce skuteczny czujnik.
Jak mówi dr L. Evans, jeden z głównych autorów projektu oraz główny badacz w MGH’s Wellman Center for Photomedicine:
– Nasze badanie wykazało, że opracowany przez nasz zespół płynny przezroczysty bandaż mierzy utlenowanie tkanek z porównywalną skutecznością do standardowego oksymetru. Nasz bandaż to ponadto znaczący postęp w stosunku do przewodowego oksymetru, który ogranicza ruchy pacjenta, jest skomplikowany w użyciu, utrudnia wizualną kontrolę tkanki i może dawać fałszywe odczyty – tłumaczy badacz.
Wynalazek dla wojska
Zlecenie stworzenia skutecznego, nowoczesnego czujnika natlenowania tkanek zostało skierowane do zespołu naukowców przez Departament Obrony Stanów Zjednoczonych. Głównym celem projektu było zmniejszenie odsetka odrzuconych przeszczepów skóry u żołnierzy, którzy ulegli urazom i ranom na polu walki.
Kontrola przeszczepu
Skuteczność innowacyjnego bandaża z czujnikiem natlenienia zbadano na pięciu kobietach, które przeszły rekonstrukcję piersi w następstwie nowotworu. Obszar skóry o powierzchni 1 cm x 1 cm pokryto warstwą bandaża i monitorowano natlenienie tkanki przez 48 godzin po operacji. Działanie bandaża zostało porównane ze standardowym oksymetrem.
Badanie wykazało, że bandaż skutecznie mierzy ilość tlenu docierającą bezpośrednio do tkanek, natomiast zwykły oksymetr odczytuje poziom nasycenia krwi tlenem za pomocą spektorskopii w bliskiej podczerwieni, co oznacza mniej dokładny pomiar.
W kolejnych badaniach klinicznych badacze zamierzają sprawdzić, czy bandaż może pomóc we wskazaniu przeszczepu, który może zostać odrzucony przez organizm z powodu niewystarczającej podaży tlenu.
Szerokie zastosowanie
Autorzy projektu wskazują, że ich wynalazek ma szerokie zastosowanie w medycynie. Bandaż mierzący poziom tlenu może zostać wykorzystany m.in. w leczeniu ran, w przeszczepach tkanek po urazach i oparzeniach, a także w leczeniu kończyn zajętych chorobami układu krążenia takimi jak przewlekłe niedokrwienie lub choroba tętnic obwodowych.
Źródło: eurekalert.org
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