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Chirurgiczny hydrożel zapobiega powstawaniu pooperacyjnych zrostów i blizn

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Naukowcy z Południowego Uniwersytetu Medycznego w Chinach opracowali chirurgiczny hydrożel do wstrzykiwań, który zapobiega powstawaniu zrostów i blizn po mało inwazyjnych operacjach. Preparat zatrzymuje nadmierny rozrost tkanek bliznowatych, a także zapobiega odkładaniu się kolagenu.

HAD – hydrożel opracowany przez ekspertów chińskiego uniwersytetu – będzie można podawać podczas małoinwazyjnych zabiegów, np. laparoskopowych. Oprócz działania zapobiegawczego dla tworzenia się zrostów i blizn, preparat posiada również właściwości przeciwzapalne.

Skuteczny i kompatybilny preparat

U 90 proc. pacjentów poddawanych otwartej operacji jamy brzusznej lub miednicy rozwija się tkanka bliznowata – informują chińscy naukowcy.  Prof. Yaobin Wu z Południowego Uniwersytetu Medycznego w Chinach zwraca uwagę, że większość hydrożeli do wstrzykiwań dostępnych na rynku działa dwustronnie, zwiększając tym samym ryzyko powstania zrostów pooperacyjnych. Z kolei preparaty z jednostronną adhezją, zdaniem eksperta, mogą zmniejszać ryzyko zrostów, jednak proces ich przygotowania sprawia, że nie nadają się do wstrzykiwań podczas zabiegu chirurgicznego.

Opracowany przez naukowców hydrożel posiada właściwości do zatrzymywania rozrostu tkanek i może być stosowany w przypadku minimalnie inwazyjnych zabiegów chirurgicznych. Hydrożel posiada jednostronną adhezję, zasklepia ranę i skutecznie zapobiega powstawaniu zrostów pooperacyjnych. HAD składa się z ligandów polianionowych w połączeniu z kwasem hialuronowym. Po wstrzyknięciu preparatu strona hydrożelu, która nie ma kontaktu z raną, utwardzana jest światłem UV przez 3 do 5 sekund. Promieniowanie UV zapobiega przyleganiu hydrożelu do innych miejsc. Związek okazał się również kompatybilny z komórkami ludzkimi.

Hydrożel powstrzymywał stan zapalny i zapobiegał tworzeniu się zrostów

Naukowcy przetestowali hydrożel na ranach operacyjnych m.in. u szczurów. U zwierząt, które otrzymały HAD, w porównaniu z innymi wersjami hydrożelów lub aplikowaniem soli fizjologicznej, większość stanów zapalnych ustępowała, a po 14 dniach od zabiegu nie było widocznych zrostów.  Prof. Yaobin Wu zaznaczył, że preparat jest odpowiedni i bezpieczny podczas laparotomii.

Naukowcy planują teraz kontynuowanie badań. Szczególnie skupią się na uwzględnieniu tego, w jaki sposób związki znajdujące się w hydrożelu mogą pomóc w leczeniu przewlekłych ran i zapobieganiu zrostom będącym konsekwencją różnego rodzaju urazów.

Źródło: medicalxpress.com

 

Przeczytaj także: Czym jest i na czym polega mobilizacja blizny?

 

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