Techniki sekwencjonowania genomowego oraz analiza danych pacjentów, z pomocą uczenia maszynowego, posłużyły izraelskim naukowcom, by opracować innowacyjny algorytm wspierający przepisywanie antybiotyków. W swoich badaniach eksperci skupili się m.in. na infekcjach bakteryjnych ran.
Rozwiązanie zostało opracowane przez zespół kierowany przez prof. Roya Kishonego z Technion-Israel Institute of Technology w Hajfie we współpracy z Maccabi KSM Research and Innovation Center, którym kieruje dr Tal Patalon. Naukowcy twierdzą, że zaprojektowany przez nich algorytm może nawet o połowę zmniejszyć ryzyko pojawienia się antybiotykooporności.
Dopasowanie leczenia antybiotykami dla każdego pacjenta
Naukowcy wyjaśniają, że leczenie infekcji bakteryjnych skupia się na wyborze antybiotyku, który odpowiada wrażliwości patogenu. Tymczasem nawet dopasowane leczenie może zakończyć się niepowodzeniem w wyniku pojawiającej się oporności drobnoustrojów.
– Chcieliśmy zrozumieć, w jaki sposób pojawia się oporność na antybiotyki podczas leczenia i znaleźć sposoby na lepsze dostosowanie leczenia antybiotykami dla każdego pacjenta, aby nie tylko prawidłowo dopasować obecną podatność pacjenta na infekcje, ale także zminimalizować ryzyko nawrotu infekcji i uzyskać oporność na leczenie – podkreślił prof. Kishon.
W przeprowadzonych badaniach naukowcy skupili się na dwóch typach infekcji bakteryjnych. Z pomocą sekwencjonowania całego genomu i analizy uczenia maszynowego przeanalizowano 1113 izolatów bakteryjnych przed i po leczeniu, 140 349 historii pacjentów z infekcją dróg moczowych oraz 7 365 zakażeń ran. Eksperci odkryli, że pojawienie się oporności można przewidzieć, a także zminimalizować je na poziomie indywidualnego pacjenta.
Szansa na poprawę skuteczności leczenia infekcji
Jak wyjaśniają badacze, bakterie mogą ewoluować przez losowe nabywanie mutacji, co czyni je opornymi na antybiotyki. Losowość tego procesu utrudnia przewidywanie i uniknięcie rozwoju oporności. Eksperci z Izraela odkryli jednak, że w przypadku większości infekcji, u przeważającej części pacjentów, oporność nie została nabyta przez przypadkowe mutacje. Zakażenia powodują głównie własne bakterie jelitowe pacjenta (mikrobiom). Dlatego zaproponowano dopasowanie antybiotyku nie tylko do podatności bakterii wywołujących obecną infekcję, ale także do bakterii w ich mikrobiomie, które mogłyby je zastąpić.
– Odkryliśmy, że podatność na antybiotyki wcześniejszych infekcji pacjenta może być wykorzystana do przewidywania ryzyka nawrotu opornej infekcji po leczeniu antybiotykami. Wykorzystanie tych danych wraz z danymi demograficznymi pacjenta, takimi jak wiek i płeć, pozwoliło nam opracować algorytm – podkreślił dr Mathew Stracy, pierwszy autor artykułu, biochemik z Technion, który pracuje również na Oxford University w Wielkiej Brytanii.
Naukowcy mają nadzieję, że opracowane przez nich rozwiązanie znajdzie szerokie zastosowanie w leczeniu infekcji bakteryjnych, co z kolei wpłynie na poprawę skuteczności i zminimalizowanie rozprzestrzeniania się oporności drobnoustrojów.
Źródło: PAP
Przeczytaj także: Czujnik w nieinwazyjny sposób wykrywa wczesne oznaki infekcji rany
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I was curious if you ever thought of changing the page layout of your website? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having one or two images. Maybe you could space it out better?
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Awesome blog! Do you have any recommendations for aspiring writers? I’m hoping to start my own website soon but I’m a little lost on everything. Would you suggest starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m totally confused .. Any tips? Many thanks!
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This post is the highlight of my Monday! It’s wonderfully written and full of insights. Incorporating more visuals could make your future posts even more engaging and enjoyable.
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