Naukowcy ze szwajcarskiego centrum badawczego Empa opracowali nowy materiał opatrunkowy, który reaguje na temperaturę w ranie związaną z infekcją. Gdy temperatura wzrośnie do co najmniej 37 stopni Celsjusza ze struktur materiału uwalniany jest środek o działaniu przeciwdrobnoustrojowym.
Zespół naukowców ze Szwajcarii zaprojektował kompatybilny materiał z cienkiej membrany z nanowłókien, który składa się z polimeru PMMA (polimetakrylanu metylu) oraz Eudragitu, biokompatybilnej mieszaniny polimerów, która wykorzystywana jest do powlekania tabletek. W nanowłóknach opatrunku zamknięto środek antyseptyczny – oktenidynę, która działa bójczo na bakterie, grzyby i niektóre wirusy. W leczeniu ran oktenidyna hamuje wzrost bakterii w łożysku rany, a także utrzymuje wilgotne środowisko rany oraz znacznie przyspiesza jej gojenie.
Opatrunek reaguje na temperaturę w ranie
O zakażeniu rany może świadczyć kilka objawów, m.in. zaczerwienienie rany, ból, pieczenie, uczucie pulsowania rany, obrzęk, ropna wydzielina, a także osłabienie, złe samopoczucie i gorączka. Manifestacją infekcji jest także wzrost temperatury w ranie.
Szwajcarscy naukowcy postanowili zaprojektować opatrunek tak, by był w stanie odczytywać temperaturę rany. Gdy utrzymuje się ona w zakresie 32-34 stopni Celsjusza środki antybakteryjne pozostają w strukturach opatrunku. Jeżeli dojdzie natomiast do wzrostu temperatury rany – do co najmniej 37 stopni Celsjusza – materiał opatrunkowy ulega zmiękczeniu i uwalnia do rany oktenidynę. Spadek temperatury rany do pożądanego poziomu powoduje, że polimer w opatrunku twardnieje, zamykając w swych strukturach środek przeciwbakteryjny. Ładunek leku zamknięty w materiale starcza na podanie 5 dawek oktenidyny.
Uwolnienie oktenidyny wpływa na zmniejszenie liczby bakterii w ranie
W badaniach laboratoryjnych eksperci sprawdzili działanie opracowanej metody przeciw bakteriom gronkowca i pałeczki ropy błękitnej. Naukowcy dowiedli, że uwolnienie oktenidyny zmniejszyło około 1000-krotnie liczbę bakterii. Dr Fei Pan, który współkieruje zespołem naukowców, podkreśla, że dzięki opracowanemu rozwiązaniu rany mogą być leczone w razie potrzeby i we właściwym momencie. Wpływa to więc na oszczędność środków przeciwdrobnoustrojowych, a także ogranicza ryzyko rozwoju patogenów opornych na działanie leków.
Badacze dopracowują obecnie swój wynalazek, tak by materiał był wrażliwszy na zmianę temperatury w ranie. Ponadto eksperci planują zastosować inne leki, które mogłyby być dostarczane przez opatrunek.
Źródła: medicalxpress.com, newatlas.com, laboratoria.net
Przeczytaj także: Antyseptyki w leczeniu ran. Najważniejsze informacje

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