Newsy Obok slidera Zespół stopy cukrzycowej

Nowa metoda leczenia zespołu stopy cukrzycowej opracowana przez naukowców z San Diego

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Naukowcy z ośrodka badawczego Scripps Research Institute opracowali nową metodę leczenia owrzodzeń powstałych w przebiegu ZSC z wykorzystaniem małocząsteczkowego leku PY-60, który stymuluje mechanizmy gojenia tkanek. Badania kliniczne mają się rozpocząć w przyszłym roku.

Nowa metoda leczenia polega na miejscowym stosowaniu leku, który oddziałuje na białko kontrolujące tempo wzrostu i regeneracji tkanki. Dzięki temu możliwe jest przyspieszenie podziału komórek w miejscu urazu i znaczne skrócenie procesu leczenia ran przewlekłych. Wyniki badań opublikowano w czasopiśmie naukowym „Nature Chemical Biology”.

Nieznane białko

W centrum zainteresowania naukowców z ośrodka Scripps Research Institute znalazł się gen YAP1, który odgrywa w ludzkim organizmie ważną rolę w procesie regeneracji tkanek. YAP1 czynnikiem transkrypcyjnym genów, które odpowiadają za proliferację komórek, a jednocześnie tłumi aktywność genów odpowiedzialnych za apoptozę.

Aktywność genu YAP1 jest kontrolowana przez ścieżkę sygnałową Hippo. Odpowiada ona za regulację procesów proliferacji i apoptozy. Naukowcy z San Diego odkryli nieznane wcześniej białko ścieżki Hippo, które współpracuje z YAP1 w celu przekazywania informacji o gęstości komórek. Kiedy organ lub tkanka osiąga odpowiednią gęstość, komórki przestają rosnąć.

Naukowcy odkryli, że poprzez stymulację tego białka za pomocą nowego leku PY-60 można ponownie aktywować proces namnażania komórek, co sprawia, że proces leczenia przebiega szybko i bez efektów ubocznych.

Obiecujące wyniki badań

Naukowcy przetestowali skuteczność nowej metody leczenia na modelach zwierzęcych oraz na odpowiednikach ludzkich tkanek (próbki skóry hodowane w warunkach laboratoryjnych). Wstępne testy dowiodły, że zastosowanie leku pozwoliło na podwojenie grubości zewnętrznej warstwy skóry w ciągu tygodnia. Autorzy projektu liczą na rozpoczęcie badań klinicznych w następnym roku.

Liczne zastosowania kliniczne

Jak podkreśla prof. Michael Bollong, główny autor projektu z ośrodka Scripps Research Institute, nowa metoda leczenia może znaleźć zastosowanie nie tylko w terapii ran trudno gojących się. Ekspert wyjaśnia, że odkrycia poczynione przez jego zespół mogą stanowić pierwszy krok do opracowania nowych metod leczenia chorób serca i wątroby, a także chorób zapalnych jelit.


Przeczytaj także: Inteligentny tatuaż – jakie ma zastosowanie w diagnostyce i leczeniu ran?

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