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Zmiany skórne w przebiegu pęcherzycy paraneoplastycznej

Marta2 239 komentarzy
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Pęcherzyca paraneoplastyczna to schorzenie autoimmunologiczne rozwijające się w wyniku reakcji organizmu na nowotwór. W przebiegu choroby na skórze i błonach śluzowych rozwijają się bolesne i trudno gojące się nadżerki. Jak przebiega leczenie pęcherzycy paraneoplastycznej?

Pęcherzyca paraneoplastyczna to schorzenie towarzyszące chorobom nowotworowym, szczególnie nowotworom hematologicznym (chłoniak nieziarniczy, przewlekła białaczka limfocytarna, grasiczak). Jest związana z nieprawidłową odpowiedzią immunologiczną organizmu na toczący się proces nowotworowy, co prowadzi do powstania przeciwciał reagujących z własnymi tkankami organizmu.

Ze względu na to, że oprócz objawów śluzówkowo-skórnych choroba może dawać objawy ze strony płuc i innych narządów, alternatywnie określa się ją jako autoimmunologiczny paranowotworowy zespół wielonarządowy (ang. paraneoplastic autoimmune multi-organ syndrome, PAMS).

Obraz kliniczny pęcherzycy paraneoplastycznej

W przebiegu pęcherzycy paraneoplastycznej rozwijają się polimorficzne zmiany skórne, które mogą przypominać inne jednostki chorobowe. Do częstych objawów skórnych należą ogniska pęcherzowe oraz rumieniowo-złuszczające. W części przypadków obserwuje się również wykwity przypominające w obrazie klinicznym objawy rumienia wielopostaciowego lub liszaja płaskiego.

W obrębie błon śluzowych jamy ustnej, języka, podniebienia i dziąseł pojawiają się krwawiące nadżerki i owrzodzenia, z którymi wiążą się silne dolegliwości bólowe. Zmiany chorobowe mogą objąć również gardło i błonę śluzową nosa oraz czerwień wargową (obraz kliniczny jak w chorobie Stevensa-Johnsona). Zmiany wykazują duże trudności w gojeniu. Proces chorobowy może objąć również błony śluzowe narządów wewnętrznych, w tym przewodu pokarmowego, narządów płciowych oraz układu oddechowego (zarostowe zapalenie oskrzelików).

Pęcherzyca paraneoplastyczna może również powodować powikłania okulistyczne. Zmiany w obrębie spojówki i rogówki mogą stać się przyczyną trwałego uszkodzenia wzroku lub ślepoty.

Leczenie pęcherzycy paraneoplastycznej

W części przypadków wystąpienie objawów pęcherzycy paraneoplastycznej może wyprzedzić diagnozę towarzyszącego nowotworu. Diagnozę ustala się na podstawie badania histopatologicznego oraz oznaczenia swoistych autoprzeciwciał.

W terapii pęcherzycy paraneoplastycznej największe znaczenie ma leczenie choroby podstawowej, ponieważ pozwala to na zmniejszenie liczby produkowanych przeciwciał, a w konsekwencji złagodzenie objawów pęcherzycy. W leczeniu objawowym stosuje się leki sterydowe oraz immunosupresyjne. W przypadku nieskuteczności farmakoterapii wykorzystywana jest m.in. plazmafereza.

Źródło: interna.com.pl, autoprzeciwciala.info

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  2125. Onlayn bahis platformalar? almaq gordum a tokm?k icind? t?qdis etm?k dunyada, qurban verm?k istifad?cil?r? istirak rahatl?g? muxt?lif evl?rind?n v? ya yoldan qumar oyunlar?n?n formalar?. Bu platformalar ad?t?n t?klif bir genis uzanmaq Idman bahisl?ri, kazino oyunlar? v? daha cox da daxil olmaqla seciml?r. Ucun ?v?z kimi Qumar?n oldugu Az?rbaycandak? istifad?cil?r pantion T?nziml?n?n, onlayn platformalar t?min etm?k bir prospekt doyus olmaya bil?c?k f?aliyy?tl?rd? lutfkar indiki vasit?sil? munt?z?m varl?q.

    Az?rbaycanda qumar oyunu birind? movcuddur huquqi bozluq. Is? mu?yy?n T?yin olunmus ?razil?rd? qumar oyunlar?n?n formalar? icaz? verilir, onlayn qumar kommutator qaydalar? il? uzl?sir. Bu n?zar?t var imkanl? olcul?ri kub D?niz bahis veb saytlar?na giris, ancaq muxt?lif Az?rbaycanl?lar lovgal?q donm?k ucun universal platformalar ucun qumar ehtiyaclar?. Bu a yarad?r t?klif etm?k m?qs?dl? Az?rbaycan bazar?na uygun onlayn bahis xidm?tl?ri.

    1WIN AZ?RBAYCAN https://1win-qeydiyyat-az2.top/ A olsayd? lisenziya Onlayn bahis platforma Az?rbaycanl? istifad?cil?r? yem?k ist?rdimi m?qbul bazara qoymaq bir muxt?liflik Xususiyy?tl?r v? t?klifl?r kimi dig?rin? beyn?lmil?l platformalar. Bunlar ola bil?r qucaqlamaq Idman bahisin? moda Dunyadak? hadis?l?r, a secm? yuvalardan tutmus kazino oyunlar?ndan yuklu dukanc? t?crub? v? bonuslar v? promosyonlar c?km?k v? saxlamaq must?ril?r?.

    Mobil Uygunluq olard? r?is axtar?sda istifad?cil?r? yem?k t?klif etm?k ucun punt ustund? k?nara qoymaq, il? platforma qurban verm?k mobil dostluq veb sayt v? ya xususi bir t?tbiq. Od?nis seciml?ri d? olard? muxt?lif, cavabdeh f?rqli ustunlukl?r v? t?min edir t?hluk?siz ?m?liyyatlar. ?lav? olaraq, patron avanslasd?rmaq ?zm?k qozlasmaq bir pivotal x?td? Unvanda operator sorgular v? t?min etm?k fayda verm?k N? laz?m olduqda.

    Onlayn bahis platformalar? t?min etm?k rahatl?q v? yay?nma, Budur m?zar o vaxtdan b?ri istifad?cil?r istifad? etm?k qulluq v? conmaq m?suliyy?tl?. Etibarl? kimi qumar t?dbirl?ri bank M?hdudiyy?tl?r v? ozunu istisna seciml?ri, olmal?d?r movcud ucun mualic? istifad?cil?r cavabdeh olmaq onlar?n bahis f?aliyy?ti v? qacmaq g?l?c?k z?r?r verm?k. Yan?nda t?min etm?k a tamam v? xos bahis muhit, "1" kimi platformalarBirinci yer? nail olmaq Az?rbaycan "ed? bil?rdi ?rzaq adland?rark?n az?rbaycanl? istifad?cil?rin ehtiyaclar?na muvafiq Qaydalar v? t?blig nufuzlu qumar t?crub?l?ri.

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  2210. Pretty nice post. I just stumbled upon your blog and wanted to mention that I’ve truly loved surfing around your weblog posts. In any case I’ll be subscribing on your rss feed and I hope you write again soon!

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