Naukowcy z University of Birmingham opracowują produkt w aerozolu, który ma pomóc w leczeniu owrzodzeń i bliznowaceń w obrębie jamy ustnej u pacjentów cierpiących na pęcherzowe oddzielanie się naskórka.
Pęcherzowe oddzielanie się naskórka (łac. epidermolysis bullosa, EB) to grupa rzadkich genodermatoz charakteryzujących się występowaniem na skórze całego ciała bolesnych, tworzących rozległe nadżerki i owrzodzenia pęcherzy.
Leczenie zmian w jamie ustnej
Zmiany chorobowe w przebiegu EB mogą się rozwijać także w obrębie błon śluzowych jamy ustnej i przełyku, co znacząco utrudnia pacjentowi codzienne funkcjonowanie. U chorego występują trudności z jedzeniem i przełykaniem, a także z czynnościami higienicznymi takimi jak mycie zębów. W przypadku rozległego bliznowacenia mogą występować problemy z mówieniem.
Naukowcy z University of Birmingham Healthcare Technologies Institute oraz Institute of Inflammation and Ageing we współpracy z ekspertami z dziedziny dermatologii i dentystyki pracują nad formułą produktu, który pozwoli zmniejszyć nasilenie objawów EB w jamie ustnej. Projekt jest sponsorowany przez organizację charytatywną DEBRA, która działa na rzecz znalezienia lekarstwa na EB.
Nowatorska formuła
Prof. Liam Grover, który kieruje projektem, wyjaśnia, że w jego ośrodku naukowym opracowywane są formuły hydrożeli, które mogą się przyczepiać do wilgotnych tkanek wewnątrz jamy ustnej. Naukowcy chcą wykorzystać tę właściwość w celu złagodzenia objawów EB. Naukowcy chcą stworzyć produkt w aerozolu, który będzie można rozpylać bezpośrednio w jamie ustnej. Produkt ma zawierać cząsteczki przeciwzwłóknieniowe, dzięki którym będzie skuteczny w leczeniu owrzodzeń i zapobiegnie powstawaniu blizn.
W ramach projektu zaplanowano stworzenie trzech różnych formuł, z których każda będzie zawierać odrębną molekułę przeciwzwłóknieniową. Wszystkie formuły zostaną przebadane w porównawczych testach klinicznych. Cały projekt rozplanowano na dwa lata.
Pomoc dla pacjentów
Jak powiedziała Caroline Collins, dyrektor badań w fundacji DEBRA:
– Stworzenie takiego aerozolu może pomóc ograniczyć ból i dyskomfort, jaki pacjenci z EB odczuwają każdego dnia. Połączenie tej formy podania i składników przeciwdziałających włóknieniu może sprawić, że pacjenci będą w stanie normalnie jeść i dbać o higienę jamy ustnej. Jestem bardzo wdzięczna naukowcom z Birmingham za ten projekt.
Źródło: https://www.news-medical.net/
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