Rosnąca oporność drobnoustrojów na antybiotyki to jeden z najpoważniejszych problemów współczesnej medycyny, w tym również leczenia ran. Odkrycie naukowców z Purdue University może stanowić znaczący krok naprzód w walce z lekoopornymi bakteriami, poprawić wyniki leczenia, a nawet uratować życie wielu pacjentów.
Naukowcy z College of Pharmacy i College of Veterinary Medicine w ośrodku naukowym Purdue University odkryli molekułę, która wykazuje skuteczność przeciwko wankomycynoopornemu szczepowi enterokoków (vancomycin-resistant enterococcus, VRE). Wyniki ich badań zostały opublikowane w czasopiśmie naukowym „Journal of Medicinal Chemistry”.
Molekuła została stworzona dzięki zaadaptowaniu do nowego celu leku, który dotychczas był stosowany w terapii jaskry, zastoinowej niewydolności serca oraz innych problemów zdrowotnych. Jak podkreślają autorzy projektu, nowo opracowana molekuła ma szczególne właściwości.
Skuteczność i zdolność dostosowania
Jak tłumaczy Daniel Flaherty, adiunkt chemii medycznej i farmakologii molekularnej z Purdue University, jeden z autorów badań, opracowane przez jego zespół cząsteczki wykazują nie tylko silne działanie przeciwbakteryjne, ale również zdolność adaptacji do działania w różnych częściach ludzkiego organizmu. Jak wyjaśnia ekspert:
– Możemy opracować cząsteczki, które będą wykorzystywane w leczeniu systemowych zakażeń VRE, ale dzięki zmianie właściwości cząsteczek możemy również zaprojektować związek, który będzie działał np. wyłącznie w przewodzie pokarmowym, gdzie występuje największa kolonizacja VRE. Dzięki współpracy naukowców z wielu wydziałów na Purdue University byliśmy w stanie zwiększyć skuteczność leku przeciwko VRE o 600 razy.
Jak wyjaśnia prof. Mohamed Saleem, kolejny współautor projektu, możliwość dostosowania cząsteczki do selektywnego działania w wybranych partiach organizmu jest niezwykle istotna. Naukowiec porównuje nowatorską molekułę z antybiotykami, które zazwyczaj mają szerokie spektrum działania i z tego powodu niszczą również bakterie o pozytywnym działaniu i źle wpływają na organizm. To kolejny problem, w którym odkrycie jego zespołu mogłoby pomóc.
Zakażenia ran przewlekłych i pooperacyjnych
Odkrycie amerykańskich naukowców może mieć duże znaczenie dla leczenia ran trudno gojących się. Enterokoki wankomycynooporne mogą powodować zakażenia odleżyn i ran oparzeniowych, a także ran pooperacyjnych. Infekcja tymi patogenami znacznie wydłuża i utrudnia proces gojenia rany i może stanowić przyczynę poważnych powikłań.
Enterokoki stanowią jedne z najważniejszych szpitalnych patogenów. Łatwo rozprzestrzeniają się w środowisku szpitalnym dzięki dużej odporności na czynniki fizyko-chemiczne i zdolności do długotrwałej kontaminacji powierzchni. Opcje terapeutyczne w przypadku tego drobnoustroju są wciąż bardzo ograniczone, dlatego odkrycie naukowców z Purdue University może mieć przełomowy charakter.
Źródło: https://www.eurekalert.org/
Przeczytaj także: Jak pandemia koronawirusa wpłynęła na opiekę nad pacjentami z cukrzycą?
http://gjgjgjgdgs.com
150821 154276Intriguing web site, i read it but i still have a few questions. shoot me an email and we will talk far more becasue i might have an intriguing thought for you. 94844
Thank you a lot for giving everyone an exceptionally wonderful chance to read from this blog. It really is so superb and stuffed with fun for me personally and my office fellow workers to search the blog the equivalent of three times weekly to read through the fresh issues you have got. And of course, we are certainly pleased with the mind-boggling information served by you. Selected 2 points in this article are essentially the best we have had.
Some really excellent content on this internet site, regards for contribution.
Precisely what I was searching for, thankyou for posting.
Good ?V I should definitely pronounce, impressed with your site. I had no trouble navigating through all the tabs as well as related info ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, web site theme . a tones way for your customer to communicate. Nice task..
983643 111092Its truly a cool and useful piece of info. Im glad that you shared this beneficial details with us. Please maintain us informed like this. Thanks for sharing. 896184
I conceive other website owners should take this internet site as an example , very clean and excellent user genial design and style.
Hey! Do you know if they make any plugins to protect against hackers? I’m kinda paranoid about losing everything I’ve worked hard on. Any recommendations?
soft music
I¦ve been exploring for a little for any high-quality articles or blog posts in this sort of area . Exploring in Yahoo I at last stumbled upon this website. Studying this information So i am happy to express that I’ve an incredibly excellent uncanny feeling I came upon exactly what I needed. I such a lot no doubt will make sure to don¦t forget this web site and give it a look on a relentless basis.
I have been examinating out some of your articles and i can claim pretty nice stuff. I will definitely bookmark your blog.
You got a very excellent website, Glad I found it through yahoo.
This is the right blog for anyone who wants to find out about this topic. You realize so much its almost hard to argue with you (not that I actually would want…HaHa). You definitely put a new spin on a topic thats been written about for years. Great stuff, just great!
Aw, this was a very nice post. In idea I would like to put in writing like this additionally – taking time and precise effort to make an excellent article… but what can I say… I procrastinate alot and certainly not appear to get something done.
I’ve been absent for a while, but now I remember why I used to love this website. Thank you, I?¦ll try and check back more frequently. How frequently you update your website?
Hello, i believe that i noticed you visited my weblog so i came to “go back the favor”.I am attempting to in finding issues to enhance my website!I suppose its ok to make use of a few of your ideas!!
Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point. You clearly know what youre talking about, why throw away your intelligence on just posting videos to your site when you could be giving us something enlightening to read?
relaxing jazz music
I like reading through and I think this website got some truly useful stuff on it! .
Hello. impressive job. I did not imagine this. This is a impressive story. Thanks!
Hmm it seems like your website ate my first comment
(it was extremely long) so I guess I’ll just sum it up what I wrote and say,
I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger
but I’m still new to everything. Do you have any tips for novice blog writers?
I’d definitely appreciate it.
I conceive this website has very good indited subject matter posts.
I was examining some of your blog posts on this website and I think this internet site is really instructive! Continue putting up.
You have observed very interesting details! ps decent site.
Hi my friend! I wish to say that this article is amazing, nice written and include almost all significant infos. I’d like to see more posts like this.
Hey there just wanted to give you a quick heads up. The text in your post seem to be running off the screen in Ie. I’m not sure if this is a format issue or something to do with internet browser compatibility but I figured I’d post to let you know. The layout look great though! Hope you get the issue resolved soon. Thanks
This is the right web site for everyone who would like to find out about this topic.
You know a whole lot its almost tough to argue with you (not that I really
would want to…HaHa). You definitely put a brand new spin on a topic which has been written about for many years.
Great stuff, just excellent!
What i do not understood is in fact how you are no longer really a lot more well-preferred than you might be now. You’re so intelligent. You realize thus considerably on the subject of this subject, made me in my opinion consider it from a lot of varied angles. Its like women and men don’t seem to be fascinated unless it is something to accomplish with Woman gaga! Your personal stuffs excellent. Always take care of it up!
Having read this I thought it was very informative. I appreciate you taking the time and effort to put this article together. I once again find myself spending way to much time both reading and commenting. But so what, it was still worth it!
This really answered my problem, thank you!
576354 731288I like the way you conduct your posts. Have a nice Thursday! 445279
Your style is so unique compared to many other people. Thank you for publishing when you have the opportunity,Guess I will just make this bookmarked.2
outdoor coffee
I reckon something genuinely special in this web site.
Hi i am kavin, its my first time to commenting
anyplace, when i read this paragraph i thought i could also create comment due to this brilliant paragraph.
Admiring the persistence you put into your site and detailed information you provide. It’s nice to come across a blog every once in a while that isn’t the same unwanted rehashed information. Fantastic read! I’ve bookmarked your site and I’m adding your RSS feeds to my Google account.
Metal scrap reclaiming facility Ferrous scrap incident response Iron scrap reclamation solutions
Ferrous material reclaiming technology, Iron scrap assessment, Scrap metal scrap yard
Scrap metal recovery and reuse Ferrous material facility management Iron scrap disposal facility
Ferrous material market intelligence, Iron recovery industry, Scrap metal reclamation methodologies
Hello.This article was extremely motivating, particularly since I was looking for thoughts on this subject last Thursday.
Helpful info. Lucky me I found your web site accidentally, and I am surprised why this twist of fate did not happened earlier! I bookmarked it.
Scrap metal processing plant Ferrous material supplier relationships Iron waste reusing services
Ferrous material material reuse, Iron redistribution, Metal waste dismantling
995244 547762Following study a lot of with the content within your internet site now, and i also truly considerably like your way of blogging. I bookmarked it to my bookmark internet site list and are checking back soon. Pls take a appear at my web page also and inform me how you feel. 737049
I was reading some of your articles on this internet site and I conceive this internet site is real informative! Retain putting up.
Metal waste reclaiming facility Ferrous material reclamation solutions Iron scrap remolding
Ferrous material sorting technology, Iron scrap reclamation yard, Metal reclamation and recycling
Your ability to distill complex concepts into enjoy readingable content is admirable.
You have remarked very interesting details ! ps decent site.
I like this web site so much, bookmarked. „American soldiers must be turned into lambs and eating them is tolerated.” by Muammar Qaddafi.
I always learn something new from your posts. Thank you for the education!
This article is a perfect blend of informative and entertaining. Well done!
This post is a testament to your expertise and hard work. Thank you!
Hmm it seems like your blog ate my first comment (it was extremely long) so I guess I’ll just sum it up what I wrote and say, I’m thoroughly enjoying your blog. I too am an aspiring blog blogger but I’m still new to everything. Do you have any tips for rookie blog writers? I’d genuinely appreciate it.
Its great as your other posts : D, appreciate it for putting up. „As experience widens, one begins to see how much upon a level all human things are.” by Joseph Farrell.
Merely wanna state that this is very beneficial, Thanks for taking your time to write this.
Your passion for this subject shines through your words. Inspiring!
What Is Puravive? Puravive is a weight loss supplement that works to treat obesity by speeding up metabolism and fat-burning naturally.
This article was a delightful enjoy reading. Your passion is clearly visible!
This is one of the most comprehensive articles I’ve enjoy reading on this topic. Kudos!
Your post was a beacon of knowledge. Thank you for illuminating this subject.
This article is a perfect blend of informative and entertaining. Well done!
You’ve presented a complex topic in a clear and engaging way. Bravo!
The insights dazzled me more than a candlelit dinner. Thanks for lighting up my intellect.
This post is a testament not only to The expertise but also to The dedication. Truly inspiring.
naturally like your web site but you need to check the spelling on several of your posts. A number of them are rife with spelling problems and I find it very troublesome to tell the truth nevertheless I will certainly come back again.
I have been absent for a while, but now I remember why I used to love this blog. Thank you, I’ll try and check back more often. How frequently you update your site?
Spot on with this write-up, I actually think this web site wants much more consideration. I’ll most likely be again to read way more, thanks for that info.
That is very attention-grabbing, You’re a very skilled blogger. I’ve joined your rss feed and look forward to searching for extra of your great post. Also, I’ve shared your site in my social networks!
What a compelling enjoy reading! Your arguments were well-presented and convincing.
Your house is valueble for me. Thanks!…
Thanks for sharing your thoughts. I truly appreciate your efforts and I am waiting for your further post thank you
once again.
I appreciate the clarity and thoughtfulness you bring to this topic.
This is a brilliant piece of writing. You’ve nailed it perfectly!
Fitspresso stands out among the crowded health supplement market as an exceptional product.
you have a great blog here! would you like to make some invite posts on my blog?
Everything is very open and very clear explanation of issues. was truly information. Your website is very useful. Thanks for sharing.
This was a great enjoy reading—thought-provoking and informative. Thank you!
I’m still learning from you, but I’m trying to achieve my goals. I certainly enjoy reading everything that is posted on your site.Keep the information coming. I liked it!
I’m impressed by your ability to convey such nuanced ideas with clarity.
This piece was beautifully written and incredibly informative. Thank you for sharing!
„Your unique perspective on this topic was truly enlightening. It’s refreshing to encounter such passion and new ideas in your field, and it’s evident that you are deeply invested in this subject.”
„Thank you for the clear explanations throughout your article. They greatly enhanced my understanding of the topic, and your methodical approach to the subject matter is truly helpful.”
The way you articulate The thoughts is as refreshing as the first sip of coffee in the morning.
The Writing is a treasure trove of knowledge, like finding an untouched library book. A rare gem!
You’ve done a fantastic job of breaking down this topic, like unlocking a door to a secret garden. Intrigued to explore more.
The article was a joy to read, and The enthusiasm is as infectious as The charm.
The unique perspective is as intriguing as a mystery novel. Can’t wait to read the next chapter.
I am continuously invstigating online for posts that can help me. Thanks!
I loved The fresh take on this topic. The points resonated with me deeply.
A gift for explaining things, making the rest of us look bad.
The words are like brush strokes on a canvas, painting ideas in my mind.
The posts inspire me regularly. The depth you bring to The topics is truly exceptional.
Engaging with The content is like embarking on a treasure hunt, where knowledge is the prize.
Tonic Greens, a natural health supplement, is designed to enhance immune function.
Renew is not just another sleep aid; it’s a comprehensive nutritional formula
Renew is a nutritional supplement launched in 2024 to help anyone lose weight.
The breadth of The knowledge is amazing. Thanks for sharing The insights with us.
I have learn several excellent stuff here. Certainly worth bookmarking for revisiting. I surprise how much effort you put to make one of these excellent informative website.
Good ?V I should definitely pronounce, impressed with your website. I had no trouble navigating through all tabs as well as related info ended up being truly simple to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, website theme . a tones way for your customer to communicate. Nice task..
SightCare is a vision enhancement aid made of eleven carefully curated science-backed supplements to provide overall vision wellness.
I was more than happy to find this net-site.I wanted to thanks to your time for this glorious read!! I definitely having fun with each little little bit of it and I have you bookmarked to take a look at new stuff you blog post.
Awesome post.
Nice post. I used to be checking constantly this weblog and I’m impressed! Extremely helpful info specifically the ultimate part 🙂 I deal with such information a lot. I used to be looking for this certain information for a long time. Thank you and good luck.
Having read this I believed it was really enlightening.
I appreciate you taking the time and energy to put this informative article together.
I once again find myself personally spending a lot of time both reading and commenting.
But so what, it was still worth it!
I like what you guys are up also. Such intelligent work and reporting! Keep up the excellent works guys I’ve incorporated you guys to my blogroll. I think it will improve the value of my website 🙂
I¦ve been exploring for a little bit for any high quality articles or weblog posts on this kind of space . Exploring in Yahoo I ultimately stumbled upon this website. Reading this information So i am happy to convey that I’ve an incredibly just right uncanny feeling I discovered just what I needed. I most definitely will make certain to do not omit this site and provides it a glance regularly.
Dead indited content material, appreciate it for entropy.
Making hard to understand topics accessible, you’re like the translator I never knew I needed.