Naukowcy z Wielkiej Brytanii opracowali silikonową powłokę do implantów, która zawiera lek przeciwzapalny i może radykalnie zmniejszyć wystąpienie niepożądanej reakcji układu odpornościowego na ciało obce w organizmie. Rozwiązanie wpływa również na prawidłowe gojenie się tkanki wokół implantów.
Obecnie stosowane wszczepialne elektroniczne urządzenia medyczne, takie jak rozruszniki serca czy implanty ślimakowe, mogą nieść za sobą pewne zagrożenia dla pacjenta. Niejednokrotnie zdarza się, iż organizm traktuje te implanty jako ciała obce. Dochodzi wówczas do obronnej reakcji zapalnej, w której komórki odpornościowe próbują zniszczyć urządzenie. Naukowcy z University of Cambridge opracowali powłokę dla implantów z lekiem przeciwzapalnym, co może znacznie zmniejszyć ryzyko odrzucenia implantu.
W badaniach na myszach leki zawarte w implantach zahamowały reakcję zapalną
Eksperci, by ocenić skuteczność wynalazku, przeprowadzili badania na modelach zwierzęcych. Myszom zostały wszczepione urządzenia elektroniczne, które miały zrekompensować uszkodzenia nerwu kulszowego. Implanty pokryte zostały silikonową powłoką z zawartością leków przeciwzapalnych i cząsteczki MCC950. Naukowcy przeanalizowali występowanie reakcji zapalnej w tkance otaczającej implant. Podczas badań odkryto, że dodanie do powłoki wszczepianego urządzenia cząsteczki MCC950 zahamowało aktywność cząsteczki NLRP3, która odgrywa kluczową rolę w występowaniu reakcji zapalnej. Opracowane przez naukowców rozwiązanie znacznie zmniejszyło więc ryzyko odrzucenia implantów, a wokół wszczepionych urządzeń nie pojawiała się blizna. Ponadto rozwiązanie to nie utrudniało procesu regeneracji nerwów.
Substancje hamujące działanie NLRP3 są opracowywane przez wiele ośrodków klinicznych w celu leczenia chorób zapalnych, nowotworów, posocznicy, choroby Alzhaimera czy choroby Parkinsona. Obecnie prowadzone są badania kliniczne nad opracowaniem inhibitorów hamujących cząsteczkę NLRP3.
Rozwiązanie może zmniejszyć odsetek odrzucania implantów
Naukowcy mają nadzieję, że ich rozwiązanie poprawi jakość życia osób, które potrzebują długodziałających implantów, by przezwyciężyć niepełnosprawność czy poważną chorobę. Stosowanie leków przeciwzapalnych z cząsteczką MCC950 w implantach może znacznie zmniejszyć odsetek odrzucenia przez organizm ciała obcego, umożliwi prawidłowe gojenie się tkanki wokół implantów i ograniczy ryzyko wymiany implantu. Badacze zwracają uwagę, że ich rozwiązanie może mieć również ogromny wpływ na neuroprotetykę (protetykę, która łączy się z układem nerwowym), ponieważ w przypadku implantów, które muszą stymulować nerw, niejednokrotnie powstawanie tkanki bliznowatej wokół implantu ogranicza jego funkcjonalność.
Źródła: PAP, newatlas.com
Przeczytaj także: Antybakteryjna powłoka zapobiega zakażeniom implantów ortopedycznych
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