Castaneroxy A to cząsteczka, którą naukowcy z Uniwersytetu Emory w USA wyekstrahowali z liści kasztanowca europejskiego. Związek wykazuje zdolność niszczenia cząsteczek lekoopornego gronkowca złocistego (MRSA) i hamuje ich zdolność do komunikowania się ze sobą oraz produkowania zjadliwych toksyn.
– Udało nam się wyizolować nową dla nauki cząsteczkę, która występuje w bardzo małych ilościach w liściach kasztanowca europejskiego. Cząsteczka ta rozbraja opornego na metycylinę gronkowca złocistego poprzez neutralizowanie zdolności tej bakterii do wytwarzania toksyn – wyjaśnia prof. Cassandra Quave, starsza autorka badań z Wydziału Dermatologii na Uniwersytecie Emory.
Castaneroxy A neutralizuje szkodliwe działanie gronkowca
Nazwa wyekstrahowanej cząsteczki – Castaneroxy A – pochodzi od nazwy kasztanowca europejskiego Castanea. Inspiracją naukowców do podjęcia próby wyizolowania związku była tradycyjna medycyna stosowana w ludowych ośrodkach leczniczych we Włoszech, gdzie okład z gotowanych liści kasztanowca przykłada się na skórę w celu leczenia oparzeń, wysypki czy zainfekowanej rany.
Pierwsze testy wyekstrahowanej cząsteczki przeprowadzone zostały na zakażonym gronkowcem modelu mysim. Badania potwierdziły skuteczność cząsteczki Castaneroxy A w ograniczaniu rozprzestrzeniania się bakterii, a także w przyspieszaniu gojenia się zakażonej rany. Udowodniono, że cząsteczka neutralizuje szkodliwe działanie gronkowca złocistego i nie powoduje zwiększania oporności bakterii. W badaniach prowadzonych pod kierunkiem prof. Quave naukowcy przygotowali specjalny ekstrakt, którego skład opiera się na cząsteczkach liści kasztanowca. Wykazali, że zahamował on zdolność komórek gronkowca złocistego do komunikowania się ze sobą, a w efekcie uniemożliwił wytwarzanie większej ilości zjadliwych toksyn.
Nowe strategie walki z infekcjami bakteryjnymi
– Kładziemy podwaliny pod nowe strategie walki z infekcjami bakteryjnymi na poziomie klinicznym. Zamiast nadmiernie skupiać się na zwalczaniu patogenu, koncentrujemy się na lepszym leczeniu pacjenta. Dzięki osłabieniu działania gronkowca pozwalamy, by układ odpornościowy organizmu samodzielnie zwalczył infekcję lub by antybiotyki skuteczniej zabijały drobnoustroje – mówi prof. Quave.
Autorzy badania wyjaśniają że gronkowiec złocisty jest jednym z najpoważniejszych czynników powodujących choroby zakaźne na całym świecie.
– Pilnie potrzebujemy nowych strategii i działań w celu odkrywania leków przeciwbakteryjnych, które działają inaczej niż tradycyjne antybiotyki. Infekcje wywołane przez gronkowca złocistego zabijają każdego roku około 700 tys. osób na całym świecie. Zgodnie z przewidywaniami liczba ta będzie nadal rosła, jeżeli nie wprowadzimy nowych metod leczenia – podkreśla prof. Quave.
Źródło: sciencedaily.com
Przeczytaj także: Stany zapalne i pęcherze objawami grzybicy odzwierzęcej
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이러한 환불 정책에도 8년 이상의 운영을 하면서 단 1건의 환불 요청도 없었던 특별한 카지노사이트입니다.
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메이저라는 뜻은 여러가지 의미가 있지만 대중적으로 가장 많이 쓰이는 의미로는 규모가 큰 조직이나 거대한 권력 집단을 의미합니다.
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