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W jaki sposób estrogen wpływa na rozwój czerniaka? Nowe badania w USA

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Kobiece hormony płciowe mogą mieć związek z rozwojem nowotworów skóry – wskazują badania przeprowadzone przez amerykańskich naukowców. Odkrycie to może się przyczynić do opracowania nowych metod leczenia czerniaka i innych typów nowotworów.

Jak dowodzą liczne badania naukowe, estrogeny odgrywają istotną rolę w patogenezie raka piersi. Najnowszy projekt przeprowadzony przez amerykańskich naukowców z Duke University School of Medicine oraz University of North Carolina at Chapel Hill dowiodły, że hormon ten może mieć również wpływ na rozwój nowotworów skóry.

Wyniki badań opublikowano w czasopiśmie naukowym „Journal of Clinical Investigation”.

Czerniak zamaskowany jako rana

Naukowcy z Duke University zaobserwowali, że chorujący na czerniaka mężczyźni, którzy są poddawani leczeniu inhibitorami punktów kontrolnych układu odpornościowego, osiągają lepsze efekty niż kobiety poddawane tej samej terapii. Przeprowadzone następnie badania dowiodły, że przyczyną różnic w efektywności leczenia czerniaka są prawdopodobnie estrogeny.

Jak wyjaśnia prof. Donald McDonnell z Duke University, jeden z autorów projektu, jest to związane z tym, w jaki sposób kobiece hormony płciowe wpływają na działanie układu odpornościowego w obecności nowotworu:

Estrogeny modulują działanie układu odpornościowego na guz nowotworowy poprzez stymulowanie aktywności makrofagów. Makrofagi stymulują wzrost guza poprzez zwiększenie dopływu krwi i blokadę działania limfocytów T. Obecność makrofagów w obrębie guza sprawia, że organizm traktuje go jako ranę w procesie leczenia  – wyjaśnia ekspert.

Nowe terapie dla różnych typów nowotworów

W oparciu o uzyskane wnioski badacze przeprowadzili testy na modelach zwierzęcych z wykorzystaniem leku Fulvestrant, którego działanie polega na blokowaniu receptorów estrogenowych. Terapia pozwoliła zahamować wzrost czerniaka poprzez aktywację limfocytów T. Lek zwiększył również efektywność immunoterapii.

Jak podsumowuje prof. Scott Antonia, jeden z naukowców zaangażowanych w projekt, odkrycie jego zespołu może mieć przełożenie na praktykę kliniczną w zakresie leczenia nie tylko czerniaka, ale również innych rodzajów nowotworów, w tym raka płuc oraz raka jelita:

– Guzy nowotworowe opierają się immunoterapii dzięki obecności makrofagów w obrębie guza. Zmniejszenie poziomu tych komórek poprzez blokadę działania estrogenu może stanowić ważną strategię w leczeniu różnych rodzajów nowotworów.

Badacze planują rozpoczęcie badań klinicznych nad nowatorską terapią z udziałem ludzi.

Źródło: news-medical.net

 

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