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Szczep bakterii odpowiedzialnej za trądzik może chronić skórę przed gronkowcem

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Jak dowiodły badania przeprowadzone przez naukowców z Osaka City University, określone szczepy bakterii C. acnes mogą pozytywnie wpływać na odpowiedź immunologiczną komórek skóry przeciwko gronkowcowi złocistemu.

Zespół naukowców z Japonii przeprowadził badania na nicieniach z rodzaju Caenorhabditis elegans, które dowiodły, że poszczególne szczepy bakterii C. acnes odgrywają inne role w kontakcie ze skórą. Szczepy patogeniczne RT4 i RT8 mogą być przyczyną wystąpienia trądziku, natomiast szczep RT6, występujący naturalnie na zdrowej ludzkiej skórze, zapobiega infekcji bakteriami S. aureus.

Wyniki badań opublikowano w czasopiśmie naukowym „Microbiology Spectrum”, należącym do organizacji American Society for Microbiology.

Badania na nicieniach

Jak wyjaśnia Ayano Tsuru, jeden z głównych autorów projektu, w badaniach wdrożono innowacyjne podejście, które polegało na wykorzystaniu nicieni zamiast ssaków. Nicienie z rodzaju Caenorhabditis elegans posiadają podstawowe struktury zwierzęcego organizmu, takie jak system nerwowy, tkanka mięśniowa czy układ trawienny. Mają również powierzchnię ciała odpowiadającą ludzkiej skórze. Naukowcy z Osaka City University wykorzystali nicienie, by zbadać działanie biologiczne różnych szczepów bakterii C. acnes na ludzką skórę.

Wyniki badań wykazały, że szczepy rybotypowe 4 i 8 (RT 4 i RT 8), które występują na skórze osób chorujących na trądzik, skróciły czas życia nicieni. Szczep RT6, naturalnie występujący na skórze zdrowej, nie miał natomiast negatywnego wpływu na nicienie.

Skuteczność przeciwko gronkowcom

W kolejnym etapie badań naukowcy sprawdzili, czy szczepy C. acnes, które naturalnie występują na zdrowej skórze, będą miały wpływ na podatność nicieni na zakażenie bakterią S. aureus.

Wyniki badań wykazały, że nicienie zarażone C. acnes przeżywały w kontakcie z S. aureus dłużej niż nicienie z grupy kontrolnej. Jak wskazuje prof. Shuta Tomida z ośrodka Center for Comprehensive Genomic Medicine at Okayama University Hospital, który brał udział w projekcie, badania dowodzą, że C. acnes nie hamuje wzrostu patogenów, tylko wzmacnia odporność wrodzoną organizmu.

Naukowcy dowiedli tego z wykorzystaniem sekwencjonowania RNA zmian w ekspresji genów. Pozwoliło to wykazać, że szczepy C. acnes aktywowały grupę genów związanych z wrodzoną odpornością nicieni i biologiczną odpowiedzią immunologiczną.

Nowe probiotyki

Jak wskazują autorzy projektu, wyniki badań rzucają nowe światło na rolę bakterii, która dotychczas była postrzegana przez naukę wyłącznie jako patogen. Może się to przyczynić do rozwoju w dziedzinie badań nad probiotykami, które obecnie są skupione na szczepach bifidobacteria oraz lactobacillus. Szczepy C. acnes o pozytywnym wpływie na ludzką skórę mogą zostać w przyszłości wykorzystane jako alternatywa dla najpopularniejszych probiotyków.

Źródło: sciencedaily.com

 

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