Dermatologia Newsy Obok slidera

Remetinostat obiecujący w leczeniu raka podstawnokomórkowego

Ten tekst przeczytasz w 2 min.

Remetinostat to żel będący inhibitorem deacetylazy histonowej. W drugiej fazie badań klinicznych preparat wykazał oznaki skuteczności u pacjentów z rakiem podstawnokomórkowym (BCC). Zdaniem naukowców remetinostat może być bezpieczną alternatywą dla chirurgicznego leczenia nowotworu.

Remetinostat to pierwszy w swojej klasie inhibitor deacetylazy histonowej (HDAC) przeznaczony do stosowania miejscowego. Zespół badaczy kierowany przez Kavitę Sarin z Uniwersytetu Stanforda zidentyfikował zdolność hamowania HDAC jako obiecującą formę terapii raka podstawnokomórkowego.

Skuteczność preparatu zbadano łącznie na 49 guzach

Badania kliniczne drugiej fazy przeprowadzono wśród 30 dorosłych pacjentów, u których zidentyfikowano co najmniej jeden guz nowotworowy o średnicy 5 mm lub większej. Remetinostat został przetestowany łącznie na 49 guzach, które znajdowały się w różnych częściach ciała pacjentów (zarówno w miejscach wystawionych na działanie słoneczne, jak i nienaświetlanych).

Uczestnicy badania nakładli żel remetinostat na swoje guzy trzy razy dziennie przez sześć tygodni. Po ośmiu tygodniach, pozostałości guza usunięto chirurgicznie i zbadano histopatologicznie.

Większość zmian nowotworowych odpowiedziała na leczenie remetinostatem

33 zmiany nowotworowe w 69,7 proc. odpowiedziały na leczenie miejscowe, w tym 17 guzów odpowiedziało całkowicie, a 6 częściowo. Średnica guza zmniejszyła się średnio o 62,3 proc., a całkowita powierzchnia o 71,5 proc. Odpowiedź na leczenie zaobserwowano w wielu podtypach BCC: powierzchownej (5 odpowiedzi całkowitych, 1 częściowa), guzkowej (10 odpowiedzi całkowitych, 5 częściowych) oraz naciekających (2 pełne odpowiedzi). Jedynie wśród dwóch guzów podtypu mikroguzkowego nie zaobserwowano odpowiedzi na leczenie.

W trakcie badania nie zaobserwowano żadnych ogólnoustrojowych lub poważnych zdarzeń niepożądanych. Niektórzy pacjenci zgłaszali jedynie łagodne reakcje skórne w miejscu podania preparatu, podobne do egzemy.

Obiecujące wyniki badań

– Chociaż potrzebne są dalsze badania, nasze wyniki sugerują, że remetinostat może być bezpieczną i obiecującą alternatywą dla leczenia chirurgicznego raka podstawnokomórkowego ze względu na wysoki wskaźnik całkowitych odpowiedzi, który zaobserwowaliśmy – zaznacza Kavita Sarin.

Zdaniem eksperta, jeśli terapia ma zastąpić leczenie chirurgiczne, musi wywołać nie tylko pełną odpowiedź na leczenie, ale także trwałą. Dlatego kolejne badania nad remetinostatem będą skupiać się właśnie na tym aspekcie.

Czym jest rak podstawnokomórkowy?

BCC jest złośliwym nowotworem skóry wywodzącym się z nierogowaciejących komórek warstwy podstawnej naskórka. Czynnikami rozwoju raka podstawnokomrówkowego jest ekspozycja na promienie UV, immunosupresja, przewlekłe zakażenia np. wirusem brodawczaka czy HPV.

Zmiany pojawiają się najczęściej na odkrytych częściach ciała i rozwijają się głównie na skórze głowy i szyi (powieki, czoło, nos, policzki). Nieleczony nowotwór może przyczyniać się do powolnego niszczenia coraz większego obszaru przyległej skóry oraz głębszej struktury ciała, np. chrząstki nosa czy kości czaszki. Zmiany mogą naciekać sąsiadujące elementy kostne, chrzęstne, naczyniowe, nerwowe lub gałkę oczną. Raka podstawnokomórkowego cechują niewielkie owrzodzenia z wałowatym brzegiem. Inną postacią nowotworu są guzki nietorbielowate.

Leczenie nowotworu odbywa się za pomocą radykalnego usunięcia zmiany wraz z marginesem zdrowych tkanek. W przypadkach, gdy zabieg chirurgiczny jest niemożliwy, w praktyce klinicznej wdraża się radioterapię, a w razie rzadkich przerzutów – chemioterapię.

Przeczytaj także: Powstał materiał opatrunkowy o właściwościach skóry

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Chirurgia Plastyczna i Oparzenia”:

104 thoughts on “Remetinostat obiecujący w leczeniu raka podstawnokomórkowego

  1. I may need your help. I’ve been doing research on gate io recently, and I’ve tried a lot of different things. Later, I read your article, and I think your way of writing has given me some innovative ideas, thank you very much.

  2. Great items from you, man. I have be aware your stuff previous to and you are simply extremely great. I actually like what you’ve received here, certainly like what you are saying and the best way through which you say it. You are making it entertaining and you continue to care for to stay it smart. I cant wait to read much more from you. This is really a terrific web site.

  3. 767760 236553An intriguing discussion will probably be worth comment. I believe that you just write significantly much more about this topic, it may become a taboo topic but usually consumers are inadequate to communicate in on such topics. To an additional. Cheers 825447

  4. It is perfect time to make some plans for the future and it’s time to
    be happy. I have read this post and if I could
    I wish to suggest you few interesting things or suggestions.
    Maybe you could write next articles referring to this article.
    I desire to read more things about it!

  5. I wish to get across my passion for your generosity giving support to people who must have assistance with this important theme. Your very own dedication to getting the message along came to be extremely invaluable and has really permitted professionals like me to arrive at their targets. This important recommendations implies a great deal a person like me and somewhat more to my office workers. Many thanks; from all of us.

  6. I am really inspired along with your writing talents and also with the format on your weblog. Is that this a paid theme or did you customize it yourself? Either way stay up the excellent quality writing, it is uncommon to peer a nice blog like this one these days..

  7. Good – I should definitely pronounce, impressed with your site. I had no trouble navigating through all the tabs as well as related info ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, web site theme . a tones way for your client to communicate. Nice task..

  8. Greetings! I know this is kinda off topic but I was wondering if you knew where I could find a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having problems finding one? Thanks a lot!

  9. Heya i am for the first time here. I found this board and I in finding It really useful & it helped
    me out a lot. I am hoping to present one thing back and help others such as you aided
    me.

  10. First off I would like to say great blog! I had a quick question in which I’d like to ask if
    you do not mind. I was interested to know how you center yourself and clear your head before writing.
    I’ve had a difficult time clearing my mind in getting my thoughts out.
    I truly do enjoy writing however it just seems like the first 10 to 15 minutes
    are lost simply just trying to figure out how to begin. Any suggestions or hints?
    Appreciate it!

  11. Wonderful work! That is the kind of information that are meant to be shared around the net.
    Disgrace on Google for not positioning this
    post upper! Come on over and discuss with my website .
    Thanks =)

  12. When I initially commented I appear to have clicked the
    -Notify me when new comments are added- checkbox and from now on whenever a
    comment is added I receive four emails with the same comment.

    Is there a means you can remove me from that service? Thanks!

  13. I’m amazed, I have to admit. Seldom do I encounter a blog that’s equally educative and interesting, and without
    a doubt, you have hit the nail on the head. The issue is something that not enough people are speaking intelligently about.
    I am very happy that I came across this during my hunt for something
    relating to this.

  14. Howdy I am so excited I found your blog, I really found you by
    error, while I was researching on Bing for something else, Anyhow I am here now
    and would just like to say thanks for a tremendous post and a all round enjoyable blog (I also
    love the theme/design), I don’t have time to look over it
    all at the moment but I have book-marked it and also added your
    RSS feeds, so when I have time I will be back to read much
    more, Please do keep up the superb jo.

  15. Greate pieces. Keep posting such kind of info on your page.
    Im really impressed by it.
    Hi there, You have performed an excellent job. I will certainly digg it and
    in my view suggest to my friends. I’m confident they
    will be benefited from this web site.

  16. Hi, I do believe this is an excellent site. I stumbledupon it 😉
    I may come back yet again since I saved as a favorite it.

    Money and freedom is the best way to change, may you be rich and continue to guide others.

  17. Thank you for any other magnificent article. Where else may just anybody get that kind of information in such a perfect means of writing?
    I’ve a presentation subsequent week, and I am on the
    look for such information.

  18. Whats up this is kind of of off topic but I was wondering
    if blogs use WYSIWYG editors or if you have to manually code with HTML.
    I’m starting a blog soon but have no coding experience so
    I wanted to get guidance from someone with
    experience. Any help would be enormously appreciated!

  19. Hey! This is my 1st comment here so I just wanted to give a
    quick shout out and say I really enjoy reading your articles.
    Can you suggest any other blogs/websites/forums that deal
    with the same subjects? Thanks for your time!

  20. You actually make it appear so easy with your presentation but I find this matter to be really something which I believe I might never understand. It seems too complex and very wide for me. I am having a look forward on your subsequent submit, I will try to get the cling of it!

  21. Definitely imagine that which you stated. Your favourite reason seemed to be on the net the easiest thing to understand of. I say to you, I certainly get irked while folks consider issues that they just do not know about. You managed to hit the nail upon the highest and outlined out the entire thing without having side effect , people could take a signal. Will likely be again to get more. Thanks

  22. 13063 807670Aw, this really is an extremely good post. In thought I would like to put in place writing like this moreover – spending time and actual effort to create a great article but exactly what do I say I procrastinate alot by means of no indicates appear to get something accomplished. 835117

  23. Hey! I know this is somewhat off-topic however I needed to
    ask. Does managing a well-established website such as yours take a
    massive amount work? I am completely new to
    writing a blog but I do write in my diary daily. I’d like to start a blog so I will be
    able to share my experience and views online. Please let me know if you have any
    kind of suggestions or tips for brand new aspiring bloggers.
    Thankyou!

  24. Thanks for a marvelous posting! I seriously enjoyed reading it, you can be a great author.I will make certain to bookmark your blog and definitely will come back in the foreseeable future. I want to encourage you to definitely continue your great work, have a nice weekend!

  25. Hello there, I found your website via Google while searching for a related topic, your web site came up, it looks great. I’ve bookmarked it in my google bookmarks.

  26. Hi, i think that i saw you visited my weblog thus i came to “return the favor”.I’m trying to find things to enhance my web site!I suppose its ok to use some of your ideas!!

  27. I discovered your blog site on google and check a few of your early posts. Continue to keep up the very good operate. I just additional up your RSS feed to my MSN News Reader. Seeking forward to reading more from you later on!…

  28. I’ll immediately clutch your rss as I can not to find your e-mail subscription hyperlink or newsletter service. Do you’ve any? Kindly let me realize so that I could subscribe. Thanks.

  29. I wish to show thanks to the writer just for bailing me out of this particular predicament. Just after searching through the world wide web and seeing methods which are not helpful, I assumed my entire life was done. Being alive minus the approaches to the problems you’ve sorted out as a result of your post is a serious case, and the ones that could have adversely damaged my entire career if I had not noticed your website. Your primary know-how and kindness in touching all areas was important. I don’t know what I would have done if I hadn’t come upon such a stuff like this. I’m able to at this point look ahead to my future. Thanks a lot very much for the skilled and sensible help. I will not be reluctant to recommend your web sites to any person who would like recommendations about this issue.

  30. In this grand scheme of things you actually get a B+ for effort and hard work. Where exactly you actually confused me was on all the facts. As people say, the devil is in the details… And that could not be much more correct right here. Having said that, let me inform you just what exactly did work. The writing is certainly quite powerful and this is probably the reason why I am making an effort in order to comment. I do not really make it a regular habit of doing that. Second, while I can certainly see the jumps in logic you come up with, I am definitely not convinced of exactly how you appear to unite your details which in turn help to make the actual final result. For right now I will, no doubt yield to your position however trust in the near future you actually connect your facts better.

  31. I must express my thanks to this writer just for rescuing me from this type of setting. Because of researching throughout the online world and obtaining proposals which were not helpful, I thought my entire life was gone. Being alive without the approaches to the difficulties you have solved all through the posting is a crucial case, and those that might have badly damaged my career if I had not encountered your blog. Your actual knowledge and kindness in controlling every aspect was useful. I’m not sure what I would’ve done if I hadn’t come across such a step like this. It’s possible to at this moment relish my future. Thanks a lot so much for your reliable and amazing guide. I will not think twice to propose your web page to anybody who needs guidance about this area.

  32. Hello very cool website!! Man .. Beautiful .. Superb .. I will bookmark your blog and take the feeds also…I am glad to seek out a lot of useful information here in the post, we need work out more techniques in this regard, thanks for sharing. . . . . .

  33. I’m impressed, I have to say. Actually rarely do I encounter a blog that’s both educative and entertaining, and let me inform you, you have hit the nail on the head. Your concept is excellent; the difficulty is something that not sufficient persons are talking intelligently about. I am very completely happy that I stumbled throughout this in my search for something relating to this.

  34. Greetings from Idaho! I’m bored to tears at work so I decided to browse your blog on my iphone during lunch break. I really like the information you provide here and can’t wait to take a look when I get home. I’m amazed at how quick your blog loaded on my phone .. I’m not even using WIFI, just 3G .. Anyways, wonderful site!

  35. Greetings I am so glad I found your site, I really found you by error, while I was browsing on Bing for something else, Anyways I am here now and would just like to say thanks for a incredible post and a all round thrilling blog (I also love the theme/design), I don’t have time to read it all at the moment but I have bookmarked it and also added your RSS feeds, so when I have time I will be back to read more, Please do keep up the awesome job.

  36. I?¦ll immediately seize your rss as I can’t find your e-mail subscription hyperlink or e-newsletter service. Do you’ve any? Please permit me realize in order that I may subscribe. Thanks.

  37. Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across. It extremely helps make reading your blog significantly easier.

  38. Wonderful items from you, man. I have be aware your stuff previous to and you are simply extremely great. I really like what you have got here, certainly like what you are saying and the way through which you assert it. You’re making it entertaining and you still take care of to stay it sensible. I cant wait to read far more from you. This is really a wonderful site.

  39. Aw, this was a really nice post. In concept I wish to put in writing like this additionally – taking time and precise effort to make a very good article… but what can I say… I procrastinate alot and not at all seem to get something done.

  40. Hi there are using WordPress for your blog platform? I’m new to the blog world but I’m trying to get started and create my own. Do you require any html coding knowledge to make your own blog? Any help would be greatly appreciated!

Dodaj komentarz

Twój adres e-mail nie zostanie opublikowany.