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Powstał bioaktywny opatrunek na oparzenia o właściwościach regeneracyjnych i przeciwdrobnoustrojowych

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Europejscy naukowcy opracowali bioaktywny opatrunek na oparzenia, który pomaga w zwalczaniu patogenów oraz sprzyja szybkiej regeneracji i gojeniu się skóry. Badacze spodziewają się, że ten wyrób medyczny ograniczy odsetek hospitalizacji pacjentów z ranami oparzeniowymi i związane z tym koszty opieki zdrowotnej.

Opatrunek na rany pooparzeniowe został zaprojektowany w ramach projektu PHAS, który uzyskał wsparcie finansowe z funduszu Maria Skłodowska-Curie Actions (MSCA). Zainicjowane badanie polegało na połączeniu komórek, biomateriałów i środków przeciwdrobnoustrojowych z myślą o zastąpieniu nim antybiotyków.

Opatrunek zawiera środki przeciwdrobnoustrojowe, które są skuteczną alternatywą antybiotykoterapii

Za badanie nad innowacyjnym opatrunkiem odpowiedzialny jest stypendysta Philippe Abdel-Sayed, który przetestował szereg biopolimerów do budowy biokompatybilnych rusztowań przeznaczonych do wzrostu i różnicowania się komórek progenitorowych naskórka. Takie rusztowanie ma pełnić funkcję przeszczepu skóry, wspomagać regenerację i naprawę uszkodzonej tkanki. Opatrunek zawiera w sobie również środki przeciwdrobnoustrojowe, m.in. bakteriofagi i syntetyczne dendrymery peptydowe, które posiadają wysoki stopień biozgodności i można je stosować miejscowo. Środki, które znajdują się w opatrunku, w opinii naukowców, są skuteczną alternatywą dla antybiotykoterapii.

– Opracowanie opatrunku na bazie komórek o właściwościach przeciwzakaźnych pomogłoby w naprawie uszkodzonej tkanki i celowanej kontroli zakażenia, szczególnie na początkowym etapie opieki nad pacjentem z ranami oparzeniowymi – podkreśla prof. Lee Ann Applegate, z Zakładu Chorób Układu Mięśniowo-Szkieletowego Szpitala Uniwersyteckiego w Lozannie (CHUV) w Szwajcarii.

Badacze wskazują, że opatrunek PHAS ma stanowić pierwszą linię obrony, zapewniając skórze regenerację i rozwiązując problem antybiotykoodporności.

Opatrunek przyczyni się do szybszego gojenia ran pooparzeniowych

Naukowcy podkreślają, że wyniki badań nad opatrunkiem są obiecujące. Konieczne są jednak dalsze badania, które pozwolą rozwijać tę technologię i ostatecznie doprowadzą do powstania produktu odpowiedniego do zastosowania u ludzi w leczeniu ran pooparzeniowych. Badacze planują aktualnie przetestować rozwiązanie w ramach badań przedklinicznych z wykorzystaniem dużych modeli zwierzęcych. Następnie, po uzyskaniu zgody organów regulacyjnych, we współpracy z CHUV, zespół przeprowadzi ocenę bezpieczeństwa i skuteczności opatrunku u ludzi.

Badacze zwracają uwagę, że opatrunek może zmniejszyć odsetek hospitalizacji pacjentów z oparzeniami oraz ograniczyć koszty opieki medycznej. Ponadto przyczyni się również do szybszego gojenia się ran pooparzeniowych i jednocześnie podniesie jakość życia chorych.

Źródło: cordis.europa.eu

 

Przeczytaj także: 8 najczęstszych błędów przy opatrywaniu oparzeń. Czego powinno się unikać?

 

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Chirurgia Plastyczna i Oparzenia”:

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