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Odwrócenie procesu starzenia się komórek – jest nowy sposób

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Jak wykazały symulacje koreańskich naukowców z KAIST (Korea Advanced Institute of Science and Technology), wyłączenie nowo zidentyfikowanego enzymu może odwrócić naturalny proces starzenia się komórek. Wyniki badań opublikowano na łamach czasopisma naukowego amerykańskiej Narodowej Akademii Nauk – Proceedings of the National Academy of Sciences of the United States of America. 

Stosowane dotychczas metody odwracania procesu starzenia komórkowego mogą wywoływać zmiany typu nowotworowego i  osłabiają regenerację tkanek. Istnieje więc konieczność opracowania mniej inwazyjnych metod. Poszukujący nowych mechanizmów prof. Kwang-Hyun Cho z Wydziału Inżynierii Bio i Mózgu KAIST wraz ze współpracownikami wykorzystali wiedzę dostępną w literaturze oraz materiał z własnych badań nad procesami związanymi z namnażaniem, staniem spoczynku i starzeniem się fibroblastów skóry, typu komórek znanego z naprawy ran.

Hamowanie enzymu PDK1 może odwracać starzenie komórkowe

Naukowcy opracowali symulacje modelujące interakcje między cząsteczkami, które pozwoliły na identyfikację enzymu zwanego PDK1, który potencjalnie może odwracać starzenie komórkowe. Działanie PDK1 zostało zbadane w inkubowanych starzejących się fibroblastach skóry i trójwymiarowych modelach tkanek odpowiadających skórze. Badania wykazały, że blokowanie PDK1 doprowadzało do zahamowania dwóch dalszych cząsteczek sygnałowych, co spowodowało przywrócenie komórkom zdolność do powrotu do cyklu komórkowego. W tej metodzie komórki zachowały zdolność do regeneracji zranionej skóry bez namnażania w sposób, który mógłby prowadzić do złośliwej transformacji.

– Nasze badania otwierają drzwi dla nowej generacji, która postrzega starzenie się jako odwracalne zjawisko biologiczne – powiedział prof. Kwang-Hyun Cho z Wydziału Inżynierii Bio i Mózgu KAIST.

Możliwość działania przeciwnowotworowego 

Naukowcy zalecają przeprowadzenie dalszych badań na narządach i organizmach w celu określenia pełnego efektu hamowania PDK1. Co ciekawe, gen PDK1 ulega nadekspresji w niektórych nowotworach, można więc przypuszczać, że jego hamowanie będzie miało działanie zarówno przeciwstarzeniowe, jak i przeciwnowotworowe.

Rozwój tych badań  i uzyskane wyniki pozwolą lepiej zrozumieć mechanizm starzenia się komórek i opracować sposoby zapobiegania chorobom związanych z wiekiem.

Źródło: PAP

Przeczytaj także: Rodzaje ran przewlekłych u osób starszych

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