Badania wskazują, że opracowany na bazie płytek krwi oczyszczony produkt egzosomalny przyspiesza gojenie ran niedokrwiennych. Dzięki jego zastosowaniu zregenerowana tkanka jest w pełni funkcjonalna i wolna od zbliznowaceń.
Oczyszczony produkt egzosomalny (ang. purified exosomal product, PEP) to zewnątrzkomórkowy pęcherzyk, który transportuje substancje pomiędzy komórkami, kierując się do tkanek wymagających naprawy. PEP jest produkowany jako suchy proszek, który może być długotrwale przechowywany w temperaturze pokojowej. Przed zastosowaniem proszek jest mieszany z roztworem hydrożelu i aplikowany bezpośrednio na ranę. Produkt powstał w amerykańskim ośrodku Mayo Clinic’s Center for Regenerative Medicine, który jest liderem w dziedzinie medycyny regeneracyjnej.
Przyspieszone gojenie
Wyniki badań przedklinicznych na modelach zwierzęcych, które zostały opublikowane w czasopiśmie naukowym „Theranostics”, wskazują, że pojedyncza aplikacja PEP na łożysko rany umożliwia regenerację skóry o normalnych właściwościach biomechanicznych, bez tkanki bliznowatej. Zregenerowana tkanka zawiera mieszki włosowe oraz gruczoły łojowe i potowe. Wykazuje również optymalny poziom nawilżenia.
Jak mówi dr Atta Behfar, jeden z głównych autorów projektu:
– Technologia egzosomalna umożliwia nie tylko zamknięcie rany, ale również przywrócenie dopływu krwi do tkanki. Naszym celem było stworzenie uniwersalnej terapii, która byłaby wolna od logistycznych ograniczeń związanych z konwencjonalną medycyną regeneracyjną. Prowadzimy badania nad tym, czy technologia ta może stanowić opcję terapeutyczną dla pacjentów z niegojącymi się ranami – podsumowuje ekspert.
Badania kliniczne
Zespół naukowców z Mayo Clinic rozpoczął prace nad uzyskaniem zezwolenia FDA na prowadzenie badań klinicznych nad stosowaniem PEP u osób z niegojącymi się ranami. Obiecujące wyniki badań opublikowanych w czasopiśmie „Theranostics” to pierwszy krok w tym kierunku.
Źródło: sciencedaily.com, regenerativemedicineblog.mayoclinic.org
Przeczytaj także: Powstał lek, który umożliwia regenerację nerwów po prostatektomii
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