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Nowa metoda leczenia urazów szkieletu – na czym polega?

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Zespół szwedzkich i niemieckich naukowców opracował metodę leczenia poważnych złamań kości udowej i goleniowej za pomocą substytutów kostnych i leków. Autorzy projektu widzą dla nowo opracowanej metody szerokie zastosowanie kliniczne.

Złamania i uszkodzenia kości spowodowane urazami, infekcją lub schorzeniem mogą stwarzać trudności w leczeniu. Przy najpoważniejszych urazach naturalny proces gojenia kości może zostać nawet całkowicie zahamowany. W takich przypadkach stosuje się transplantację kości. Materiał do przeszczepu pobierany jest zazwyczaj z miednicy pacjenta. Metoda leczenia uszkodzeń kości opracowana przez szwedzkich i niemieckich naukowców eliminuje konieczność transplantowania kości i pozwala na skuteczne leczenie nawet najbardziej rozległych i skomplikowanych urazów.

Wyniki badań naukowców z ośrodków w Lund i Dreźnie zostały opublikowane w czasopiśmie naukowym „Science Advances”.

Koktajl dla kości

Naukowcy z Lund i Drezna opracowali formułę złożoną z trzech składników: sztucznego materiału ceramicznego, bioaktywnego białka kostnego (rhBMP-2) oraz bisfosfonianiu, czyli związku odpowiedzialnego za ograniczenie resorpcji tkanki kostnej. Taki „koktajl” jest następnie wstrzykiwany w miejscu urazu.

Jak wyjaśnia dr Deepak Raina, badacz w dziedzinie ortopedii i kierownik projektu, takie połączenie składników pozwala na uzyskanie optymalnych rezultatów w leczeniu kości:

– Białko kostne, które wykorzystaliśmy, we wcześniejszych badaniach nie dało pozytywnych efektów, między innymi z powodu przedwczesnej wtórnej resorpcji kości. Udało się rozwiązać ten problem dzięki zastosowaniu bisfosfonianu. Umieszczenie leku w wolno wchłaniającym się substytucie kości pozwala kontrolować szybkość jego uwalniania – wyjaśnia ekspert. – Osiągnęliśmy sześciokrotne zmniejszenie ilości białka w porównaniu z poprzednimi próbami, jednocześnie indukując wzrost tkanki kostnej. Dzięki temu możliwe było wyleczenie bez komplikacji nawet poważnych złamań kości.

Metoda gotowa do wdrożenia

Dr Deepak Raina wyjaśnia, że leki i substancje wykorzystane w projekcie przez jego zespół są już zatwierdzone do leczenia kości. Innowację stanowi jedynie sposób połączenia składników. Dzięki temu nie ma przeszkód, by stosować nową metodę leczenia w warunkach klinicznych.

Źródło: sciencedaily.com

Przeczytaj także: Leczenie rany urazowej podudzia z ubytkiem skórnym – case study i zdjęcia

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