Nieprawidłowe gojenie się tkanek przyczyną powstania guza mózgu
Badania naukowe Newsy Obok slidera

Nieprawidłowe gojenie się tkanek przyczyną powstania guza mózgu

Ten tekst przeczytasz w 2 min.

Według naukowców z University of Toronto, The Hospital for Sick Children (SickKids) i Princess Margaret Cancer Center proces gojenia po urazie mózgu może pobudzić rozwój guza. Jak tłumaczą eksperci, może do tego dojść na skutek wykolejenia z powodu mutacji nowych komórek wygenerowanych w celu zastąpienia tych, które zostały utracone w wyniku urazu.

Wnioski te mogą przyczynić się do opracowania nowatorskiej terapii dla pacjentów z glejakiem, których dotychczasowe leczenie pozwala na wydłużenie życia do 15 miesięcy od diagnozy.

Do urazu mózgu może dojść na skutek urazu, infekcji bądź udaru

– Nasze dane sugerują, że prawidłowa zmiana mutacyjna w poszczególnych komórkach mózgu może zostać zmodyfikowana przez uraz, powodując powstanie guza – powiedział dr Peter Dirks, lider zespołu Dream Team, szef oddziału neurochirurgii, starszy naukowiec w programie Developmental and Stem Cell Biology w SickKids.

Badania pod kierownictwem Gary’ego Badera, profesora genetyki molekularnej w Donnelly Center for Cellular and Biomolecular Research na Wydziale Lekarskim U of T’s Temerty oraz dr. Trevora Pugha, starszego naukowca w Princess Margaret zostały opublikowane w czasopiśmie „Nature Cancer”.

– Glioblastomę można traktować jako ranę, która nigdy nie przestaje się goić – zaznaczył Peter Dirks. Jesteśmy podekscytowani tym, co nam to mówi o powstawaniu i rozwoju raka, a to otwiera zupełnie nowe pomysły dotyczące leczenia, koncentrując się na urazie i reakcji zapalnej.

Nowe subpopulacje komórek macierzystych glejaka

W celu zmapowania budowy molekularnej komórek macierzystych glejaka (GSC) eksperci wykorzystali najnowsze technologie sekwencjonowania RNA pojedynczych komórek i uczenia maszynowego. Zespół dr. Dirksa wykazał również, że to komórki macierzyste glejaka odpowiadają za inicjację i nawrót guza po leczeniu.

Naukowcy wykazali również nowe subpopulacje komórek macierzystych glejaka, które wykazują molekularne cechy zapalenia oraz są mieszane z innymi nowotworowymi komórkami macierzystymi w środku guza u pacjenta. Oznacza to, że pewna grupa glejaków formuje się nawet wiele lat przed wystąpieniem objawów u pacjenta.

Według badań, po zmutowaniu komórka, która angażuje się w gojenie ran nie przestaje się namnażać. To natomiast pobudza wzrost guza.

– Celem jest zidentyfikowanie leku, który zabije komórki macierzyste glejaka – zwrócił uwagę prof. Bader. Najpierw jednak musieliśmy zrozumieć molekularną naturę tych komórek, aby móc skuteczniej je kierować.

Badanie zostało przeprowadzone na podstawie guzów u 26 pacjentów. Naukowcy poddali analizie ok. 70 000 komórek. Wykorzystano do tego jednokomórkowe sekwencjonowanie RNA.

Źródło: eurekalert.org

Przeczytaj także: Zdalna diagnostyka owrzodzeń żylnych – jak ją przeprowadzić?

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Forum Zakażeń”:

6 953 thoughts on “Nieprawidłowe gojenie się tkanek przyczyną powstania guza mózgu

  1. I must show my thanks to you for bailing me out of this problem. After browsing through the the web and getting ways which were not pleasant, I figured my entire life was done. Living without the presence of approaches to the difficulties you’ve solved by way of your report is a serious case, as well as those that could have badly affected my entire career if I hadn’t encountered your site. The know-how and kindness in dealing with all areas was important. I am not sure what I would have done if I had not come across such a thing like this. I am able to at this point look forward to my future. Thank you so much for your high quality and amazing help. I will not hesitate to recommend your web site to anyone who should have tips on this area.

  2. My husband and i got really thankful Peter could do his homework by way of the ideas he gained from your web pages. It is now and again perplexing to just always be giving out thoughts which often men and women could have been selling. And now we see we now have the website owner to be grateful to because of that. Those explanations you made, the easy web site menu, the relationships you help foster – it is many extraordinary, and it is facilitating our son and the family consider that the topic is exciting, and that’s exceedingly vital. Many thanks for all!

  3. My spouse and i were now peaceful when Chris could finish up his survey through the entire precious recommendations he had while using the blog. It’s not at all simplistic to simply choose to be giving away information and facts which many others might have been making money from. And we fully understand we’ve got the website owner to thank for that. Most of the illustrations you’ve made, the simple web site menu, the friendships your site help to foster – it’s mostly overwhelming, and it is aiding our son in addition to our family believe that this idea is enjoyable, which is certainly extraordinarily essential. Thanks for the whole lot!

  4. I am also commenting to make you be aware of what a awesome experience my friend’s princess developed reading yuor web blog. She discovered some things, including what it is like to have a wonderful helping spirit to let the others easily fully understand specific extremely tough issues. You truly did more than my expected results. Thank you for producing such important, healthy, informative not to mention easy guidance on the topic to Julie.

  5. I truly wanted to construct a small word in order to thank you for some of the marvelous tactics you are sharing at this website. My extended internet look up has at the end been recognized with reputable facts to exchange with my company. I would declare that we readers are very endowed to live in a great website with very many outstanding professionals with very helpful techniques. I feel truly fortunate to have used your site and look forward to really more pleasurable minutes reading here. Thanks once more for all the details.

  6. I would like to get across my passion for your kind-heartedness giving support to individuals who have the need for assistance with your subject. Your real dedication to getting the message all-around had become wonderfully important and has regularly made many people much like me to realize their objectives. Your entire valuable report can mean so much to me and extremely more to my fellow workers. Many thanks; from each one of us.

  7. I simply wanted to thank you very much once again. I am not sure the things I could possibly have implemented in the absence of these basics revealed by you on such a subject. Entirely was a frightening situation in my position, but taking note of the very expert technique you resolved that took me to leap over happiness. I will be grateful for your service and even pray you recognize what a great job you are always accomplishing teaching other individuals all through your web blog. Probably you’ve never encountered any of us.

  8. I would like to express thanks to you for rescuing me from this type of challenge. Right after scouting through the world wide web and finding views which were not powerful, I believed my entire life was over. Living devoid of the solutions to the problems you have resolved by means of this website is a critical case, as well as ones which might have adversely damaged my career if I had not noticed your site. Your personal knowledge and kindness in touching all the stuff was precious. I am not sure what I would’ve done if I hadn’t discovered such a point like this. I can also at this moment look ahead to my future. Thank you so much for the impressive and amazing guide. I will not hesitate to recommend your web page to any person who would need support on this topic.

  9. I as well as my guys appeared to be following the excellent tactics found on your site and then then developed a terrible suspicion I had not thanked the blog owner for those tips. Most of the people are already for this reason joyful to learn them and have quite simply been enjoying them. We appreciate you really being well considerate and also for choosing certain decent areas most people are really needing to understand about. My personal honest regret for not saying thanks to earlier.

  10. I wanted to draft you the very small word to be able to thank you so much again for the gorgeous guidelines you’ve provided above. This is certainly shockingly open-handed of people like you to offer without restraint all that many of us could have distributed as an e book to help make some dough for their own end, most notably seeing that you could have tried it in the event you desired. These smart ideas likewise worked to be the good way to recognize that someone else have the same keenness like my personal own to find out lots more regarding this matter. I’m certain there are many more pleasurable periods up front for folks who take a look at your website.