W czasopiśmie naukowym „ACS Applied Biomaterials” pojawiły się badania ekspertów nad opracowaniem kremu, który zapobiega odmrożeniom skóry. Preparat nakładany 15 minut przed działaniem niskich temperatur zabezpiecza skórę, zmniejsza rozmiar uszkodzenia tkanek i stan zapalny.
Eksperci zwracają uwagę, iż działanie niskich temperatur może być szkodliwe nie tylko dla skóry, ale także może uszkadzać głębsze tkanki, np. mięśnie i kości powodując przy tym wtórne infekcje i stałe uszkodzenie nerwów. Zdaniem naukowców czas, który mija od powstania odmrożenia do wdrożenia leczenia może powodować obumarcie wielu komórek. Dlatego postanowili opracować strategię zapobiegawczą, która może uchronić skórę przed szkodliwym działaniem zimna.
Eksperymentalny krem znacznie zmniejszył rozmiar rany odmrożeniowej
Opracowana przez ekspertów substancja to kombinacja syntetycznych cząsteczek powszechnie stosowanych w laboratoriach do kriokonserwacji komórek – dimetylosulfotlenku (DMSO), który zapobiega tworzeniu się kryształków lodu wewnątrz komórek, oraz poli(alkoholu winylowego) (PVA), który zapobiega powstawaniu kryształków lodu w przestrzeniach między komórkami, co może uszkadzać błony.
W badaniach laboratoryjnych eksperci wykazali, że połączenie 2 proc. DMSO z 1,6 mg/ml PVA zapewniło największą, około 80 proc. przeżywalność komórek, jednocześnie chroniąc błonę komórkową i cytoszkielet. Kombinacja, którą naukowcy nazwali SynAFP, pozwoliła komórkom dzielić się i wytwarzać białko normalnie, mimo doświadczonego stresu związanego z niską temperaturą. Badacze przeprowadzili również badania na modelu zwierzęcym. SynAFP został zmieszany z komercyjnym kremem z aloesu i nałożony na skórę myszy 15 minut przed ekspozycją na zimno. Badania wykazały, iż krem zmniejszył rozmiar rany odmrożeniowej, uszkodzenie tkanek i stan zapalny. Ponadto preparat wspierał proces gojenia się urazu.
Naukowcy podkreślają, jednocześnie, że krem nie zapobiegał odmrożeniom, gdy został nałożony wcześniej, około 30 minut i więcej przed ekspozycją na zimno. Ich zdaniem oznacza to, że krem musi być nakładany na skórę dużo później, a także kilkukrotnie aplikowany. Eksperci zaznaczają, że zamierzają kontynuować swoje badania w celu opracowania skutecznego preparatu na odmrożenia.
Odmrożenie może doprowadzić do samoistnej amputacji
Odmrożenie jest bolesnym urazem, które pojawia się po wystawieniu skóry na działanie niskich temperatur poniżej 0 stopni Celsjusza lub w wyniku bezpośredniego kontaktu z lodem lub zimnym metalem. Uraz ten powstaje w wyniku spowolnienia, a następnie zatrzymania przepływu krwi w naczyniach krwionośnych, które zaopatrują skórę, tkankę podskórną oraz mięśnie w krew. W konsekwencji dochodzi do odwodnienia komórek oraz nieprawidłowego stężenia elektrolitów w ich wnętrzu i denaturacji kompleksów białkowo-lipidowych. Efektem końcowym odmrożenia jest przejściowe, a nawet całkowite obumarcie części ciała, która została narażona na niskie temperatury.
Odmrożenie najczęściej pojawia się na rękach i stopach, małżowinach usznych, policzkach oraz na nosie. Uraz objawia się piekącym bólem i zaczerwienieniem, pieczeniem skóry, zmianą jej zabarwienia, obrzękiem, pęcherzami wypełnionymi treścią surowiczą. Odmrożenia, podobnie jak oparzenia, w zależności od głębokości i zaawansowania urazu podzielone są na IV stopnie, przy czym w ostatnim, najpoważniejszym stopniu, dochodzi do powstania głębokiej martwicy, np. ścięgna lub kości. Niekiedy może dochodzić do samoistnej amputacji odmrożonej części ciała.
Źródła: medicalexpress.com
Przeczytaj także: Pierwsza pomoc przy odmrożeniach I stopnia
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