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Naukowcy stworzyli biomateriał, który wspomaga regenerację kości i naczyń krwionośnych

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Zespół badaczy z RCSI University of Medicine and Health Sciences oraz SFI AMBER Centre opracowali biomateriał, który może znaleźć zastosowanie w leczeniu rozległych urazów kości. Wyniki badań nad substancją opublikowano w czasopiśmie naukowym „Journal of Controlled Release”.

Naukowcy z dwóch ośrodków badawczych w Irlandii stworzyli biomateriał, który uwalnia zróżnicowane dawki łożyskowego czynnika wzrostu (ang. placental growth factor, PGF), dzięki czemu stymuluje procesy regeneracyjne tkanki kostnej oraz powstawanie nowych naczyń krwionośnych.

Naśladowanie naturalnych mechanizmów

W pracach nad nowym biomateriałem naukowcy inspirowali się naturalnymi mechanizmami naprawczymi, jakie zachodzą w ludzkim organizmie po urazie. Z tego względu biomateriał uwalnia najpierw dużą dawkę czynnika PGF, co prowadzi do stymulacji wzrostu nowych naczyń krwionośnych. Następnie uwalniane są niższe dawki substancji, co wspiera regenerację kości.

Stymulacja osteogenezy i angiogenezy za pośrednictwem jednego biomateriału to znaczące osiągnięcie dla naukowców z RCSI University. Jak wyjaśnia dr Eamon Sheehy, jeden z głównych autorów projektu i badacz w Tissue Engineering Research Group z ośrodka RCSI:

– Dzięki wykorzystaniu rozwiązań z zakresu mechanobiologii udało nam się nie tylko stworzyć nową opcję terapeutyczną dla urazów kości, ale również określić optymalne stężenia substancji wymagane do promowania za pośrednictwem jednego biomateriału zarówno angiogenezy, jak i osteogenezy. Regeneracja rozległych urazów kości to nadal poważne wyzwanie kliniczne. Mamy nadzieję, że opracowany przez nasz zespół biomateriał okaże się efektywny w dalszych badaniach – podsumowuje ekspert.

Szerokie spektrum zastosowania

Jak zwraca uwagę prof. Fergal O’Brien, główny badacz w projekcie oraz dyrektor działu badań i innowacji w ośrodku RCSI, wynalazek jego zespołu może w przyszłości znaleźć szerokie zastosowanie w medycynie regeneracyjnej:

– Poza leczeniem ubytków i urazów kości zaproponowane przez nasz podejście terapeutyczne może stworzyć nowe ramy dla zastosowania biomateriałów regeneracyjnych w inżynierii tkankowej. Medycyna regeneracyjna oparta na mechanobiologii może potencjalnie znaleźć zastosowanie w leczeniu urazów chrząstki i rdzenia kręgowego.

Naukowcy prowadzą obecnie badania nad możliwością wprowadzenia biomateriału do testów klinicznych.

Źródło: news-medical.net

Przeczytaj także: Badanie: immunoterapia w onkologii a zmiany skórne

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