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Naukowcy odkryli związek, który wspomaga gojenie kości i chrząstek

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Naukowcy z Queen Mary University of London zbadali i opisali substancję, który aktywnie wspiera regenerację uszkodzonej tkanki kostnej i chrzęstnej. Odkrycie może mieć duże znaczenie dla leczenia urazów kości i chrząstek, a także schorzeń degeneracyjnych dotykających te tkanki.

Zespół brytyjskich naukowców przeprowadził badania nad substancją o nazwie agrina. Wyniki testów wykazały, że związek ten stymuluje komórki macierzyste, dzięki czemu możliwa jest odbudowa zniszczonej lub zdegenerowanej tkanki kostnej i chrzęstnej.

To ważne odkrycie, ponieważ, jak podkreślają autorzy projektu, naturalne możliwości regeneracji uszkodzonej chrząstki są ograniczone. Niegojący się uraz chrząstki może natomiast prowadzić do poważnych powikłań, w tym do rozwoju schorzeń degeneracyjnych. Agrina może potencjalnie pomóc w zapobieganiu takim komplikacjom.

Lek na chorobę zwyrodnieniową stawów

Autorzy badań widzą zastosowanie dla agriny w leczeniu zwyrodnieniowej choroby stawów, dla której dotychczas brakowało skutecznej terapii farmakologicznej. Jak podkreśla dr Suzanne Eldridge, współautorka badań, wykorzystanie agriny mogłoby pomóc we wczesnym zapobieganiu rozwojowi tego schorzenia:

– Podanie agriny na wczesnym etapie leczenia, zaraz po tym jak doszło do urazu, mogłoby pozwolić na naprawę uszkodzonej chrząstki, dzięki czemu prawdopodobieństwo rozwoju choroby zwyrodnieniowej stawów byłoby dużo niższe. Naszym celem jest sprawienie, że choroba zwyrodnieniowa stawów stanie się schorzeniem leczonym za pomocą zastrzyku, a nie zabiegu chirurgicznego – tłumaczy ekspertka.

Sukcesy agriny w badaniach

Dotychczasowe wyniki badań nad skutecznością agriny w zakresie regenerowania uszkodzonej chrząstki są obiecujące.

W badaniach wykorzystano żel z zawartością agriny, który został podany w formie iniekcji bezpośrednio do uszkodzonych stawów u myszy i owiec. W przypadku myszy efekty terapii były zauważalne po 8 tygodniach. Po tym czasie stwierdzono regenerację zarówno uszkodzonych chrząstek, jak i kości. U owiec natomiast regeneracja tkanek była widoczna już po 6 tygodniach. Podanie agriny spowodowało znaczną poprawę ogólnej kondycji badanych zwierząt i zwiększyło ich aktywność ruchową.

Naukowcy planują w dalszej kolejności badania nad toksycznością agriny. Jak prognozują autorzy projektu, badania kliniczne z udziałem ludzi mogą się rozpocząć w przeciągu kilku lat.

Źródło: https://www.rynekaptek.pl/

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