Na czym polega leczenie raka z komórek Merkla?
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Na czym polega leczenie raka z komórek Merkla?

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Rak z komórek Merkla to nowotwór złośliwy, który charakteryzuje się szybkim rozwojem. Wywodzi się z komórek neuroendokrynnych skóry. Najczęściej umiejscawia się na skórze głowy i szyi. Leczenie tego nowotworu jest o tyle trudne, iż choroba ma tendencję do przerzutów.

Właśnie w związku z tym, zaleca się wykonać diagnostykę obrazową, czyli USG regionalnych węzłów chłonnych, USG/TK jamy brzusznej oraz RTG/TK klatki piersiowej. Na tego rodzaju nowotwór w Polsce choruje rocznie 2-3 osoby na milion mieszkańców, natomiast w Europie wskaźnik zachorowalności wynosi 2500 osób rocznie.

Choroba najczęściej dotyka mężczyzn, seniorów i osób, którzy wymagają opieki. Jej przyczyną jest m.in. długotrwała ekspozycja na promieniowanie słoneczne, zaburzenia układu immunologicznego, a także ekspozycja na poliomawirusa komórek Merkla. Dość często nowotwór ten występuje jednocześnie z innymi rodzajami nowotworów.

Chorobie tej nie towarzyszy ból. Sam guz jest purpurowo-fioletowego koloru. Cechą charakterystyczną tej choroby jest rozprzestrzenianie się ścieżkami limfatycznymi do regionalnych węzłów chłonnych.

– Początkowo nowotwór z komórek Merkla przyjmuje postać twardych, niebolesnych guzków, najczęściej zlokalizowanych na głowie i szyi. Zmiany występują rzadziej na nogach i rękach, jednak mogą pojawić się w każdej okolicy ciała. Zazwyczaj są to czerwone, purpurowe, fioletowe lub cieliste guzki o różnej wielkości – wyjaśnił w rozmowie z portalem zwrotnikraka.pl, prof. dr hab. n. med. Piotr Rutkowski, kierownik Kliniki Nowotworów Tkanek Miękkich, Kości i Czerniaków Narodowego Instytutu Onkologii im. Marii Skłodowskiej-Curie – Państwowego Instytutu Badawczego w Warszawie.

Rak z komórek Merkla ma agresywny przebieg

Ekspert dodał, iż do wstępnego rozpoznania dochodzi na podstawie badania fizykalnego i wzrokowego. Ponadto niezbędne jest również pobranie za pomocą biopsji materiału, w celu badania histopatologicznego. Jak podkreślił, ocena nie jest prosta, ponieważ tego rodzaju rak cechuje się niskim zróżnicowaniem i należy go odróżnić od innych podobnych nowotworów.

Rak z komórek Merkla leczy się poprzez chirurgiczne usunięcie zmiany, z zachowaniem marginesu zdrowych tkanek. Warto wziąć pod uwagę biopsję węzła wartowniczego i wycięcie blizny dość szeroko. Ponadto leczenie uzupełnia się radioterapią.

W momencie rozpoznania przerzuty do węzłów chłonnych występują u ok. połowy pacjentów

Pierwsza linia leczenia polega na leczeniu systemowym, czyli chemioterapii, podczas której używa się cisplatyny, doksorubicyny, winkrystyny czy etopozydu. Metodą, która w dużym zakresie wpływa na czas życia pacjenta jest immunoterapia, która dostępna jest jedynie dla osób w zaawansowanym stadium choroby, w ramach procedury Ratunkowego Dostępu do Technologii Lekowych (RDTL).

– Leczenie pacjentów z rakiem skóry z komórek Merkla uzależnione jest od stopnia zaawansowania choroby. W przypadku, kiedy choroba nie jest zaawansowana, stosuje się resekcję chirurgiczną, czyli wycięcie zmiany, ewentualnie z usunięciem węzłów chłonnych, jak również radio- i chemioterapię. Z kolei, gdy nie da się całkowicie usunąć guza nowotworowego jako leczenie uzupełniające stosuje się napromienianie, a czasem także leczenie systemowe – tłumaczy prof. Piotr Rutkowski.

Źródło: zwrotnikraka.pl

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  72. EyeFortin is a natural vision support formula crafted with a blend of plant-based compounds and essential minerals. It aims to enhance vision clarity, focus, and moisture balance.

  73. Amiclear is a dietary supplement designed to support healthy blood sugar levels and assist with glucose metabolism. It contains eight proprietary blends of ingredients that have been clinically proven to be effective.

  74. Gorilla Flow is a non-toxic supplement that was developed by experts to boost prostate health for men. It’s a blend of all-natural nutrients, including Pumpkin Seed Extract Stinging Nettle Extract, Gorilla Cherry and Saw Palmetto, Boron, and Lycopene.

  75. TerraCalm is an antifungal mineral clay that may support the health of your toenails. It is for those who struggle with brittle, weak, and discoloured nails. It has a unique blend of natural ingredients that may work to nourish and strengthen your toenails.

  76. Endo Pump Male Enhancement is a dietary supplement designed to assist men improve their sexual performance. This natural formula contains a potent blend of herbs and nutrients that work together to improve blood flow

  77. Glucofort Blood Sugar Support is an all-natural dietary formula that works to support healthy blood sugar levels. It also supports glucose metabolism. According to the manufacturer, this supplement can help users keep their blood sugar levels healthy and within a normal range with herbs, vitamins, plant extracts, and other natural ingredients.

  78. GlucoBerry is one of the biggest all-natural dietary and biggest scientific breakthrough formulas ever in the health industry today. This is all because of its amazing high-quality cutting-edge formula that helps treat high blood sugar levels very naturally and effectively.

  79. Kerassentials are natural skin care products with ingredients such as vitamins and plants that help support good health and prevent the appearance of aging skin. They’re also 100% natural and safe to use. The manufacturer states that the product has no negative side effects and is safe to take on a daily basis. Kerassentials is a convenient, easy-to-use formula.

  80. Sight Care is a daily supplement proven in clinical trials and conclusive science to improve vision by nourishing the body from within. The Sight Care formula claims to reverse issues in eyesight, and every ingredient is completely natural.

  81. Elevate your vitality with Alpha Tonic – the natural solution to supercharge your testosterone levels. When you follow our guidance, experience improved physical performance

  82. AquaPeace is the most in-demand ear health supplement on the market. Owing to its natural deep-sea formula and nutritious nature, it has become an instant favorite of everyone who is struggling with degraded or damaged ear health.

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