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Kannabidiol skuteczny w zwalczaniu opornych szczepów bakterii

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Badania australijskich naukowców z University of Queensland i firmy Botanix Pharmaceuticals dowiodły, że kannabidiol jest skuteczny w niszczeniu bakterii Gram-ujemnych i Gram-dodatnich oraz w zwalczaniu biofilmu. Naukowcy planują dalsze badania nad właściwościami związku.

Wyniki badań opublikowano w czasopiśmie naukowym „Communications Biology Research”. Wykazały one, że kannabidiol (CBD), czyli główny niepsychoaktywny składnik konopi indyjskich, skutecznie niszczy bakterie Gram-dodatnie i Gram-ujemne. Związek zachowuje skuteczność również przeciwko szczepom opornym na antybiotyki, w tym MRSA.

Jak powiedział dr Mark Blaskovich z University of Queensland Institute for Molecular Bioscience, który kierował projektem:

– Po raz pierwszy wykazano, że CBD zabija niektóre rodzaje bakterii Gram-ujemnych. Bakterie te mają dodatkową błonę zewnętrzną, dodatkową linię obrony, która utrudnia penetrację antybiotyków

Badania australijskiego zespołu naukowców wykazały również, że kannabidiol skutecznie zwalcza biofilm. Według naukowców działanie kannabidiolu polega na rozrywaniu zewnętrznych błon komórkowych bakterii. Dokładna analiza tego mechanizmu wymaga jednak dalszych badań.

Brak efektu oporności

Badacze z zespołu dr. Marka Blaskovicha przeprowadzili w warunkach laboratoryjnych symulację dwutygodniowego leczenia z zastosowaniem kannabidiolu. Celem badania było sprawdzenie, jak szybko bakterie poddane działaniu związku będą mutowały, próbując się uodpornić.

Wyniki badań wykazały, że nawet w przypadku zastosowania wysokich stężeń CBD bakterie nie wykształcały znaczącej odporności.

Analogi CBD z potwierdzoną skutecznością

Naukowcy australijscy przetestowali również skuteczność bakteriobójczą chemicznych analogów CBD, otrzymywanych poprzez alternacje w strukturze molekularnej związku. Wyniki badań potwierdziły, że analogi są równie skuteczne przeciwko drobnoustrojom co naturalny CBD.

Jak podkreśla dr Mark Blaskovich, to ważne odkrycie, ponieważ od lat 60. XX wieku nie odkryto i nie zatwierdzono żadnych nowych klas molekularnych antybiotyków stosowanych w zakażeniach Gram-ujemnych. Dzięki nowym badaniom możliwe będzie zaprojektowanie nowych analogów CBD, które będą miały ulepszone właściwości.

Autorzy projektu planują kolejne fazy badań klinicznych. Firma Botanix Pharmaceuticals, która uczestniczyła w badaniach, pracuje nad przełożeniem wyników badań na rynek komercyjny.

Źródło: PAP

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