Wzrost ilości dwóch białek: PARP1 i IDO1 w komórkach nowotworowych wiąże się z istotnie gorszym rokowaniem u pacjentów z czerniakiem błon śluzowych – wykazali naukowcy. Jak twierdzą, ograniczenie aktywności tych białek może poprawić wyniki leczenia tego nowotworu.
Głównymi autorami badania są dr hab. n. med. Piotr Donizy z Uniwersytetu Medycznego i Uniwersyteckiego Szpitala Klinicznego we Wrocławiu oraz prof. Mai P. Hoang z Uniwersytetu Harvarda i Massachusetts General Hospital.
– We współpracy z prof. Mai P. Hoang z Uniwersytetu Harvarda i Massachusetts General Hospital oraz gronem naukowców z 11 ośrodków naukowych z całego świata m.in. z Hiszpanii, Japonii i Tajwanu wykazaliśmy, że wzrost ilości dwóch białek, PARP1 i IDO1, w komórkach nowotworowych wiąże się z istotnie gorszym rokowaniem u pacjentów z czerniakiem błon śluzowych – powiedział dr Piotr Donizy.
Jaką rolę odgrywają w organizmie białka PARP1 i IDO1?
Naukowiec dodał, że jest to pierwsza na świecie analiza znaczenia prognostycznego obecności białek PARP1 i IDO1, która bazowała na materiale klinicznym zgromadzonym w jednej z największych na świecie grup badawczych pacjentów z tym nowotworem złośliwym.
Jak tłumaczy, białko PARP1 jest zaangażowane m.in. w naprawę uszkodzeń DNA, natomiast IDO1 jest enzymem uczestniczącym m.in. w regulacji odpowiedzi immunologicznej.
– To przełomowe badanie może być punktem zwrotnym w leczeniu tej grupy pacjentów w przyszłości, jak również może stać się punktem wyjścia do testowania klinicznego inhibitorów PARP1 i IDO1, czyli podwójnego hamowania aktywności tych dwóch białek.
Ekspert dodał, że są one obecnie testowane in vitro, bądź już stosowane w leczeniu innych nowotworów złośliwych.
Dr Dionizy zwrócił również uwagę, iż potencjalne zahamowanie aktywności obydwu białek mogłoby znacząco ograniczyć potencjał inwazyjny komórek czerniaka błon śluzowych i w przyszłości poprawić wyniki leczenia i rokowanie pacjentów z tym bardzo rzadkim nowotworem, dla których wciąż współczesna onkologia ma ograniczony zestaw opcji terapeutycznych.
Wyniki tego badania zostały opublikowane w prestiżowym czasopiśmie Cells. Czerniak błon śluzowych stanowi mniej niż 2 proc. wszystkich czerniaków występujących u ludzi. Jest źle rokującą odmianą czerniaka. Najczęściej występuje w obrębie jamy ustnej i nosowej, końcowym odcinku jelita grubego i w obrębie sromu.
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What is SightCare? Sight Care is an amazing supplement that promotes healthy eyesight and reduces dark blindness using natural ingredients.
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SightCare ingredients have the ability to promote the communication processes between the eye and the brain. They tend to enhance the production of chemical compounds that help in creating neurotransmitters. By getting these neurotransmitters to perform better, the ingredients solidify the connection between the eyes and the brain.
Introducing Claritox Pro, a natural supplement designed to help you maintain your balance and prevent dizziness.