Naukowcy z University of Washington dokonali rewizji badania z 1944 r. nad optymalną dzienną dawką witaminy C. Wyniki analizy wykazały, że zalecana przez WHO dawka może być zbyt niska dla skutecznego zapobiegania zaburzeniom gojenia ran.
Witamina C odgrywa ważną rolę w produkcji kolagenu, który jest niezbędny w procesie kształtowania tkanki bliznowatej. Badania, których wyniki opublikowano w sierpniu na łamach czasopisma naukowego „American Journal of Clinical Nutrition”, wskazują, że minimalna dzienna dawka witaminy C rekomendowana przez Światową Organizację Zdrowia (45 mg) może być zbyt niska dla zapewnienia prawidłowego procesu gojenia ran i formowania blizn.
Rewizja dotychczasowych badań
Analiza przeprowadzona przez naukowców z Waszyngtonu została oparta na badaniu przeprowadzonym w 1944 r. w ośrodku Sorby Research Institute w Sheffield. Celem tamtego badania było określenie minimalnego spożycia witaminy C wymaganego do zapobiegania szkorbutowi. Jednym z istotnych objawów szkorbutu jest zaburzenie procesu gojenia ran, dlatego w przebiegu badania uczestnikom wykonywano rany i sprawdzano, jak zmiana podaży witaminy C wpływa na gojenie. Wyniki badania w Sorby Research Institute wykazały, że minimalna dawka konieczna dla zachowania prawidłowego gojenia wynosi 10 mg witaminy C dziennie. W oparciu m.in. o te badania Światowa Organizacja Zdrowia określiła rekomendowane dzienne spożycie witaminy C na 45 mg.
Rewizja badań dokonana przez naukowców z University of Washington wskazuje jednak, że zalecana przez WHO dawka jest zbyt niska, by skutecznie zapobiegać opóźnieniu gojenia ran i osłabieniu tkanki bliznowatej. Jak wskazują autorzy nowej analizy, u pacjentów przyjmujących witaminę C w dawce 10 mg/d blizny były o 42% słabsze niż u pacjentów spożywających dziennie 80 mg witaminy C. W kontekście prawidłowego gojenia ran i tworzenia blizn średnie dzienne spożycie witaminy C powinno według autorów badania wynosić pomiędzy 75 a 110 mg. To dawka w przedziale rekomendowanym przez ośrodki National Academy of Medicine oraz European Food Safety Authority, ale jednocześnie ponad dwukrotnie większa, niż zaleca WHO.
Wyniki analizy wskazują również, że w przypadku wystąpienia stanów patologicznych związanych z niewystarczającą produkcją kolagenu (opóźnione gojenie ran, nieprawidłowa formacja blizn), spowodowanych niedoborem witaminy C, suplementacja tej witaminy musi być długotrwała i oparta na wysokich dawkach. Spożycie witaminy C w dawce 65 mg/d przez średnio 6,5 miesiąca nie przywróciło uczestnikom badania normalnej zdolności tkanek do gojenia ran.
Wytyczne wymagają aktualizacji
Badacze z Waszyngtonu wskazują, że nieprawidłowe rekomendacje dotyczące spożycia witaminy C mogą wynikać z dotychczasowego braku analiz statystycznych na zebranych danych. Naukowcy apelują o aktualizację rekomendacji, tak by zachować skuteczność profilaktyki i leczenia zaburzeń związanych z gojeniem ran.
Źródła: sciencedaily.com, academic.oup.com
Why was the ban reduced buy cialis online in usa It has been suggested that tamoxifen suppresses plasma levels of FT3 and FT4 and increases TBG level, hence, it induces hypothyroidism 2
In vitro and in vivo studies showed that the downregulation or blocking of uPAR, beta1integrin, FAK or EGFR, alone or in combination causes activation of p38 MAPK pathway resulting in a cell cycle arrest and dormancy Figure 4 40, 41 cialis order online
My spouse and i ended up being absolutely satisfied that Emmanuel managed to round up his research via the precious recommendations he was given out of your weblog. It’s not at all simplistic just to choose to be giving for free solutions which often others have been trying to sell. We really understand we have you to thank because of that. Those explanations you’ve made, the simple website navigation, the relationships you give support to promote – it’s got all fantastic, and it is facilitating our son in addition to the family reason why the concept is satisfying, and that’s pretty important. Thanks for the whole lot!
I have to express my thanks to you for rescuing me from this particular matter. Because of searching through the world-wide-web and coming across tips which were not helpful, I thought my entire life was well over. Existing devoid of the solutions to the issues you have solved all through your post is a critical case, as well as ones that might have in a negative way damaged my career if I hadn’t noticed the blog. Your primary know-how and kindness in dealing with all the things was very useful. I am not sure what I would’ve done if I had not encountered such a subject like this. It’s possible to at this point relish my future. Thanks so much for your expert and result oriented guide. I will not hesitate to recommend the sites to anybody who desires counselling on this subject matter.
I’m just writing to let you understand what a awesome discovery my cousin’s daughter experienced viewing your web page. She learned several issues, most notably what it’s like to have an excellent helping nature to make other people without difficulty know certain tortuous things. You truly surpassed visitors’ desires. Thank you for displaying the powerful, dependable, informative and also fun tips about that topic to Gloria.
I must show appreciation to this writer for rescuing me from this difficulty. After browsing throughout the world-wide-web and meeting proposals which were not pleasant, I assumed my life was gone. Being alive without the answers to the problems you’ve fixed through your good article is a serious case, as well as the ones that would have badly affected my career if I hadn’t come across your blog. Your own personal knowledge and kindness in taking care of all the stuff was very helpful. I’m not sure what I would’ve done if I had not come upon such a stuff like this. I’m able to now look ahead to my future. Thanks so much for this expert and results-oriented guide. I will not be reluctant to suggest your blog to anybody who will need care on this issue.
A lot of thanks for your own efforts on this site. Ellie really likes carrying out research and it’s really easy to see why. A lot of people learn all about the compelling manner you make great techniques through this blog and as well as welcome contribution from other individuals about this situation while my princess is without question becoming educated so much. Take pleasure in the rest of the year. You are doing a remarkable job.
I intended to send you a tiny remark just to give many thanks again for the incredible solutions you have shared on this website. It has been shockingly generous of people like you to provide extensively all that a number of us could possibly have offered for sale for an ebook in making some money for themselves, especially seeing that you could have done it if you desired. Those techniques also acted like the fantastic way to fully grasp that most people have similar dreams really like my personal own to know the truth a whole lot more when it comes to this issue. I know there are a lot more pleasant situations in the future for many who scan through your site.
I wanted to make a comment to be able to express gratitude to you for those pleasant facts you are posting here. My long internet lookup has finally been paid with awesome suggestions to go over with my great friends. I 'd declare that we site visitors actually are definitely fortunate to exist in a fabulous community with many special individuals with beneficial ideas. I feel truly privileged to have come across your web site and look forward to really more fun minutes reading here. Thanks a lot once more for all the details.
Thanks so much for providing individuals with such a marvellous opportunity to read in detail from this site. It is usually so excellent plus packed with a great time for me personally and my office mates to search the blog not less than three times per week to learn the fresh issues you have. And indeed, I’m just certainly fascinated considering the tremendous secrets served by you. Certain two ideas on this page are undeniably the most beneficial I have had.
I must express some appreciation to you just for rescuing me from this type of condition. Just after researching through the online world and coming across proposals which are not beneficial, I was thinking my life was done. Existing without the presence of answers to the issues you’ve fixed through this article content is a serious case, as well as the ones which might have in a wrong way affected my career if I had not discovered your blog. Your training and kindness in taking care of a lot of things was important. I don’t know what I would’ve done if I hadn’t come across such a point like this. I can also at this point look forward to my future. Thanks very much for this skilled and effective guide. I will not be reluctant to refer the sites to any person who needs tips about this situation.
I have to express my affection for your kindness giving support to persons who should have assistance with your concern. Your very own dedication to getting the message all through became surprisingly helpful and have frequently empowered most people much like me to realize their desired goals. Your amazing useful tips and hints signifies this much a person like me and further more to my mates. Warm regards; from each one of us.
I in addition to my guys were checking out the nice techniques on the website and all of the sudden I got an awful suspicion I never expressed respect to the blog owner for those secrets. My men ended up for this reason happy to study them and have in effect sincerely been tapping into them. We appreciate you genuinely indeed helpful as well as for making a decision on this sort of smart guides most people are really wanting to be aware of. My personal sincere apologies for not expressing gratitude to sooner.
I am a student of BAK College. The recent paper competition gave me a lot of headaches, and I checked a lot of information. Finally, after reading your article, it suddenly dawned on me that I can still have such an idea. grateful. But I still have some questions, hope you can help me.
I simply wanted to develop a simple message to be able to appreciate you for all of the remarkable facts you are writing at this site. My time-consuming internet investigation has finally been honored with extremely good information to go over with my friends and classmates. I would say that many of us website visitors are very much lucky to live in a wonderful place with so many outstanding people with very beneficial things. I feel rather blessed to have seen your entire web site and look forward to plenty of more thrilling minutes reading here. Thank you once again for everything.
I wanted to send a quick comment so as to express gratitude to you for all the pleasant ways you are giving out on this website. My rather long internet research has at the end been rewarded with really good facts to go over with my contacts. I 'd assert that most of us readers actually are rather lucky to exist in a useful site with very many outstanding people with insightful plans. I feel very grateful to have come across your entire site and look forward to some more cool moments reading here. Thank you again for a lot of things.
I have read your article carefully and I agree with you very much. This has provided a great help for my thesis writing, and I will seriously improve it. However, I don’t know much about a certain place. Can you help me? https://www.gate.io/pt-br/signup/XwNAU
I would like to show thanks to the writer just for rescuing me from this particular setting. Just after looking out throughout the the web and getting proposals which were not helpful, I was thinking my life was well over. Existing minus the strategies to the difficulties you have solved through your entire review is a serious case, and ones that could have in a negative way affected my career if I had not noticed your site. That expertise and kindness in taking care of a lot of stuff was excellent. I don’t know what I would have done if I had not discovered such a step like this. I’m able to now relish my future. Thank you so much for this specialized and amazing help. I will not be reluctant to propose your web page to any individual who needs to have direction about this topic.
I would like to show my thanks to you just for bailing me out of this trouble. After surfing throughout the the web and getting ways which are not beneficial, I assumed my entire life was done. Living minus the strategies to the problems you have resolved through this report is a crucial case, as well as the ones which could have in a negative way affected my career if I had not come across your blog post. Your good talents and kindness in dealing with the whole thing was crucial. I am not sure what I would’ve done if I had not encountered such a step like this. I’m able to now look ahead to my future. Thanks a lot very much for your reliable and results-oriented guide. I won’t be reluctant to suggest your site to any person who should receive assistance about this subject.
I wish to show some appreciation to you just for bailing me out of this instance. Because of researching throughout the the web and seeing ideas which are not productive, I was thinking my entire life was done. Existing without the presence of answers to the issues you’ve fixed through this short article is a serious case, as well as the kind that would have in a wrong way affected my entire career if I had not come across the blog. Your good understanding and kindness in handling every aspect was very useful. I don’t know what I would’ve done if I hadn’t come upon such a point like this. I can also now relish my future. Thanks so much for this specialized and amazing guide. I won’t think twice to endorse your web blog to any individual who should get guide about this subject matter.
I must express appreciation to the writer for bailing me out of this type of challenge. As a result of searching throughout the world wide web and meeting methods that were not powerful, I believed my entire life was gone. Being alive without the solutions to the issues you’ve sorted out by means of this article content is a crucial case, and the kind that could have in a negative way damaged my entire career if I hadn’t come across your website. Your main know-how and kindness in playing with a lot of things was vital. I’m not sure what I would’ve done if I had not come upon such a step like this. I am able to now relish my future. Thanks a lot very much for your high quality and effective help. I will not hesitate to refer your web blog to any person who needs and wants guidance about this issue.
Thanks so much for giving everyone an extremely nice possiblity to read in detail from here. It is often very superb and full of a lot of fun for me personally and my office co-workers to visit your blog at minimum three times a week to learn the newest stuff you have got. And indeed, I’m just always fulfilled with the impressive suggestions served by you. Some 2 points in this post are unquestionably the most impressive we’ve had.
Thanks for all of your hard work on this site. Kim enjoys conducting internet research and it’s easy to see why. Most people notice all relating to the dynamic medium you make sensible suggestions through this blog and even foster participation from some others about this point and my girl has been discovering so much. Enjoy the rest of the year. You are conducting a splendid job.
I would like to show my appreciation for your generosity giving support to persons that absolutely need assistance with this one area of interest. Your personal commitment to passing the solution all through has been unbelievably significant and has consistently helped many people just like me to reach their objectives. Your useful recommendations indicates a lot to me and extremely more to my office workers. Best wishes; from all of us.
I intended to draft you that very little word just to say thanks yet again about the gorgeous methods you’ve provided at this time. It was pretty generous with people like you to provide without restraint all that a lot of folks might have offered for an ebook in order to make some money for themselves, most notably seeing that you might well have tried it in case you considered necessary. The good tips additionally served as the easy way to fully grasp someone else have a similar dream like my personal own to realize a whole lot more related to this problem. Certainly there are numerous more pleasant moments up front for individuals who find out your blog post.
My spouse and i got quite thrilled Jordan managed to do his inquiry via the precious recommendations he obtained while using the weblog. It is now and again perplexing to just happen to be offering guidelines which often men and women have been trying to sell. And we fully grasp we have got the blog owner to give thanks to for this. The explanations you made, the simple website menu, the relationships you can give support to create – it’s most awesome, and it’s facilitating our son in addition to us feel that the issue is exciting, and that is highly essential. Thanks for the whole lot!
I would like to express appreciation to you for bailing me out of this particular crisis. Just after surfing throughout the world wide web and meeting thoughts which were not helpful, I figured my life was well over. Being alive devoid of the approaches to the problems you have sorted out all through your good write-up is a serious case, as well as those which could have in a wrong way affected my entire career if I hadn’t encountered the website. Your personal capability and kindness in controlling the whole lot was valuable. I am not sure what I would have done if I had not encountered such a step like this. It’s possible to at this time look forward to my future. Thanks so much for the professional and sensible guide. I will not hesitate to recommend your web sites to any person who desires tips on this topic.
I and also my friends have already been checking out the good thoughts on your website and so immediately I had an awful suspicion I had not thanked the blog owner for those tips. These ladies happened to be consequently excited to learn all of them and have really been taking pleasure in these things. Thanks for truly being very thoughtful and also for going for this sort of exceptional subject areas most people are really desperate to understand about. Our own sincere regret for not expressing appreciation to you sooner.
I have to express my appreciation to you just for rescuing me from this particular crisis. Right after surfing around through the internet and finding advice which are not powerful, I believed my life was done. Existing devoid of the approaches to the issues you have solved by way of this guideline is a serious case, and the kind that might have in a wrong way damaged my career if I had not noticed your website. Your primary training and kindness in dealing with every aspect was crucial. I don’t know what I would have done if I hadn’t come across such a thing like this. It’s possible to at this time look forward to my future. Thanks so much for this expert and effective help. I won’t think twice to propose your web page to anyone who will need counselling on this area.
I together with my guys have already been checking the excellent tips from your web blog then all of the sudden developed a terrible suspicion I had not thanked the web site owner for those secrets. All of the ladies came stimulated to study them and now have surely been making the most of these things. Thanks for genuinely indeed kind as well as for obtaining varieties of awesome subject matter most people are really desperate to be informed on. Our honest regret for not expressing gratitude to earlier.
My husband and i were absolutely thankful when John managed to finish off his researching through your precious recommendations he acquired from your very own web pages. It is now and again perplexing just to possibly be giving away helpful hints which some other people could have been trying to sell. Therefore we remember we’ve got the website owner to appreciate for that. These explanations you’ve made, the straightforward web site navigation, the relationships you will aid to create – it’s got many awesome, and it’s aiding our son and us believe that that content is cool, which is certainly very pressing. Thank you for all!
I have read your article carefully and I agree with you very much. This has provided a great help for my thesis writing, and I will seriously improve it. However, I don’t know much about a certain place. Can you help me? https://www.gate.io/fr/signup/XwNAU
My spouse and i have been now excited when Albert could deal with his web research from the ideas he was given in your blog. It’s not at all simplistic to simply choose to be offering guidance that some other people could have been making money from. And we also figure out we now have you to be grateful to for this. The specific explanations you have made, the easy blog navigation, the relationships you give support to promote – it’s got mostly overwhelming, and it is facilitating our son and us reckon that this topic is pleasurable, and that’s tremendously vital. Many thanks for all!
I intended to draft you a bit of note just to thank you yet again over the extraordinary basics you have provided on this website. It is simply surprisingly generous of people like you to offer unhampered just what a number of people could have advertised for an ebook to make some cash for themselves, specifically considering the fact that you could have done it in the event you desired. The principles as well worked like a great way to be certain that some people have similar keenness much like my own to understand lots more with regard to this matter. I think there are lots of more pleasant moments in the future for individuals that take a look at your site.
A lot of thanks for each of your hard work on this web page. My daughter loves going through internet research and it’s easy to understand why. All of us learn all regarding the powerful medium you present sensible guidelines by means of this web site and therefore invigorate participation from website visitors on this issue so my simple princess is without a doubt becoming educated a lot of things. Enjoy the rest of the year. You’re performing a useful job.
I simply desired to say thanks yet again. I’m not certain what I might have taken care of in the absence of these smart ideas contributed by you directly on that topic. It previously was a alarming concern in my view, nevertheless taking a look at a specialized approach you handled that made me to cry for delight. I’m happy for this work as well as sincerely hope you recognize what an amazing job you are getting into educating people today thru your site. Most probably you haven’t come across all of us.
I precisely desired to thank you very much yet again. I am not sure the things that I would’ve made to happen in the absence of the information shared by you on such area of interest. It was before a difficult matter in my opinion, however , looking at the professional style you processed that made me to leap with delight. I’m thankful for this advice and as well , wish you recognize what a powerful job that you’re providing educating people today all through your webblog. I am certain you have never got to know any of us.
I want to show my affection for your kindness giving support to women who really want assistance with in this area of interest. Your personal dedication to passing the message across had been astonishingly useful and have consistently empowered girls just like me to achieve their ambitions. Your own warm and friendly advice denotes so much to me and especially to my mates. Many thanks; from everyone of us.
buy cialis online no prescription viagra nediclon diclofenaco 100 mg para que sirve If youГў ve followed these Giants, you should know this story well
My wife and i have been now contented Emmanuel managed to carry out his survey by way of the precious recommendations he gained in your web site. It is now and again perplexing just to be making a gift of strategies other folks have been making money from. And now we figure out we now have you to appreciate for this. The main illustrations you made, the easy web site navigation, the relationships your site aid to foster – it’s many overwhelming, and it’s really making our son and the family do think the content is exciting, and that’s unbelievably pressing. Many thanks for the whole lot!
I want to show my respect for your kindness giving support to men and women who must have help with in this subject. Your real dedication to passing the message all through came to be quite valuable and have all the time empowered ladies like me to achieve their goals. Your helpful guidelines can mean so much a person like me and even more to my colleagues. Thanks a lot; from each one of us.
Thank you so much for providing individuals with such a special possiblity to read in detail from this blog. It is usually very pleasing and packed with fun for me personally and my office colleagues to visit your website at the very least three times weekly to study the newest tips you have. And lastly, I’m also at all times satisfied with your surprising creative ideas served by you. Selected 4 facts in this article are clearly the most efficient we have ever had.
Thank you so much for giving everyone remarkably breathtaking chance to read critical reviews from this website. It’s usually so beneficial and full of a good time for me personally and my office mates to search your website not less than thrice a week to read the new guidance you have. Of course, I am usually pleased concerning the cool concepts you give. Selected 1 tips on this page are undeniably the most beneficial we’ve ever had.
I simply needed to appreciate you yet again. I’m not certain the things that I might have created without the tips revealed by you directly on such problem. Certainly was an absolute fearsome dilemma in my position, nevertheless viewing your well-written approach you processed that made me to leap with gladness. Now i’m grateful for your help and then believe you recognize what a great job you happen to be carrying out educating some other people through your webpage. I am certain you haven’t got to know any of us.
I enjoy you because of each of your effort on this blog. My mom delights in going through internet research and it’s easy to understand why. Almost all hear all about the dynamic ways you convey simple tips on this blog and as well inspire response from the others on this area of interest plus my princess has been being taught a great deal. Have fun with the rest of the new year. You are always conducting a really great job.
Film izlemek, birçok farklı türdeki filmleri keşfetmek, farklı hikayeler ve karakterlerle empati kurmak, jetfilmizle.video sanatsal ifadeyi deneyimlemek, bilgi edinmek veya sadece keyifli bir zaman geçirmek için tercih edilen bir etkinliktir. Filmler, dramatik, komedi, aksiyon, bilim kurgu, gerilim, romantik, animasyon gibi çeşitli türlerde olabilir ve herkesin ilgi alanına ve zevkine hitap edecek bir film bulunabilir. jetfilmizle.com
Shown in panels D F are representative histograms gated on D b GP 33 41 CD8 T cells generic cialis cost Lindsay MNJqQzWYhmpAwbKshAo 6 17 2022
Hi there! This post couldn’t be written any better! Reading through this post reminds me of my previous room mate! He always kept talking about this. I will forward this article to him. Pretty sure he will have a good read. Thank you for sharing!
It is actually a great and helpful piece of info. I am glad that you shared this helpful info with us. Please keep us informed like this. Thanks for sharing.
Hi my friend! I wish to say that this post is amazing, nice written and come with almost all vital infos. I would like to peer more posts like this .
Rattling clear web site, thankyou for this post.
I just couldn’t go away your website before suggesting that I extremely loved the usual information an individual provide in your guests? Is going to be again regularly in order to check out new posts.
It’s really a cool and useful piece of information. I’m glad that you simply shared this helpful information with us. Please stay us up to date like this. Thanks for sharing.
chill jazz
Good write-up, I am normal visitor of one?¦s website, maintain up the excellent operate, and It is going to be a regular visitor for a lengthy time.
It’s hard to find knowledgeable people on this topic, but you sound like you know what you’re talking about! Thanks
Great delivery. Sound arguments. Keep up the great effort.
Loving the info on this web site, you have done outstanding job on the blog posts.
Please let me know if you’re looking for a writer for your
blog. You have some really good posts and I believe I would be a good asset.
If you ever want to take some of the load off, I’d love to write
some articles for your blog in exchange for a link back to mine.
Please blast me an e-mail if interested. Many thanks!
Italian Cafe Ambience
I’ve been absent for some time, but now I remember why I used to love this web site. Thanks, I will try and check back more often. How frequently you update your site?
It is in reality a great and useful piece of info. I am happy that you just shared this useful information with us. Please stay us informed like this. Thanks for sharing.
Respecting each other’s differences fosters a harmonious and accepting relationship.
Do you have a spam problem on this blog; I also am a blogger, and
I was wanting to know your situation; we have developed some nice procedures and we are looking to exchange methods with others,
be sure to shoot me an e-mail if interested.