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Badania: nowatorska terapia białkowa wspiera gojenie ran

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Naukowcy z Agency for Science, Technology and Research odkryli, że białko o nazwie agryna wspomaga gojenie się ran i regenerację tkanek uszkodzonej skóry. Badania mogą utorować drogę do opracowania terapii trudno gojących się i powikłanych ran  – m.in. stopy cukrzycowej i oparzeń.

Podczas urazu dochodzi do dużej utraty macierzy pozakomórkowej (ECM), która odgrywa ważną rolę w odbudowie tkanki. Jest substancją wypełniającą przestrzeń między komórkami skóry. W jej składzie znajdują się m.in. włókna kolagenowe i elastynowe. Znaczna utrata ECM, np. w ranach powikłanych, wpływa na opóźnienie procesu gojenia się ran. Uzupełnienie w odpowiednim czasie kluczowych białek macierzy pozakomórkowej może znacznie przyspieszyć ten proces.

Biomateriały na bazie agryny mogą wspierać gojenie się ran

Singapurscy naukowcy przeprowadzili badania, z których wynika, że terminowa indukcja lub egzogenna suplementacja agryny, modularnego proteoglikanu macierzy pozakomórkowej, może promować przyspieszone gojenie się ran. Badacze odkryli również, że rekombinowany fragment agryny – sAgrin – może służyć jako dodatkowa terapia poprawiająca gojenie się ran. Białko to można zastosować w formie hydrożelu na rany.

– Odkryliśmy, że w naszych przedklinicznych modelach gojenia ran terapia białkiem agryna zapewnia przyspieszone gojenie w porównaniu z żelami kolagenowymi dostępnymi na rynku. Oprócz szybszego gojenia ran, terapia agryną stwarzała odpowiednie mikrośrodowisko dla rany, które jeszcze bardziej wspierało mechanizmy naprawy tkanek. Odkrycia te oferują potencjał do opracowania biomateriałów do gojenia ran na bazie agryny, które mogą pomóc pacjentom z przewlekłymi ranami – wskazał dr Sayan Chakraborty, główny autor badania, które zostało opublikowane w czasopiśmie naukowym „Nature Communucations”.

Regeneracyjne właściwości agryny w uszkodzeniach kostno-chrzęstnych

We wrześniu 2020 r. Suzanne E. Eldridge z Queen Mary University of London, we współpracy z innymi ekspertami, odkryła, że agryna sprzyja regeneracji kości oraz chrząstki. Podczas badań naukowcy wstrzyknęli agrynę do stawów myszy cierpiących na ubytki kostno-chrzęstne. Okazało się, że agryna sprzyjała właściwemu i szybkiemu połączeniu się kości oraz chrząstki. Podobne efekty zaobserwowano u owiec leczonych żelem agrynowo-kolagenowym.

Źródła: sciencedaily.com, sciencemag.org

 

Przeczytaj także: Kolagen w procesie gojenia ran

 

 

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Chirurgia Plastyczna i Oparzenia”:

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