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Badacze z WUM pracują nad wykorzystaniem komórek macierzystych pochodzenia tłuszczowego w leczeniu ZSC

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Badacze z Warszawskiego Uniwersytetu Medycznego opracowują potencjalnie nową metodę leczenia pacjentów z zespołem stopy cukrzycowej. Eksperci przeprowadzą badania kliniczne nad produktem leczniczym, którego substancję czynną stanowią allogeniczne komórki mezenchymalne pozyskiwane z tkanki tłuszczowej.   

Projekt pt. „Ocena bezpieczeństwa i skuteczności produktu leczniczego terapii zaawansowanej zawierającego żywe komórki ASC w leczeniu zespołu stopy cukrzycowej – badanie podwójnie zaślepione, z randomizacją (Akronim: FootCell)” otrzymał ponad 9 mln zł dofinansowania od Agencji Badań Medycznych w konkursie na opracowanie nowych procedur diagnostycznych i terapeutycznych w obszarze chorób cywilizacyjnych.

Eksperci: wstępne wyniki badań są zachęcające

Produkt leczniczy, który potencjalnie może służyć leczeniu stopy cukrzycowej zaprojektowany, opracowany i wytworzony został w Laboratorium Badawczym – Banku Komórek Warszawskiego Uniwersytetu Medycznego pod kierunkiem prof. Małgorzaty Lewandowskiej-Szumieł. Głównym badaczem jest dr hab. Beata Mrozikiewicz-Rakowska z Kliniki Diabetologii i Chorób Wewnętrznych UCK WUM, kierowanej przez prof. Leszka Czupryniaka. Projekt, realizowany w konsorcjum z Uniwersytetem Łódzkim, uwzględnia poszukiwanie mechanizmów i działania aplikowanych komórek z zastosowaniem metod multiomicznych. Badanie kliniczne zostanie przeprowadzone dwuośrodkowo.

Eksperci podkreślają, że wstępne wyniki badań nad produktem uzyskane w Laboratorium LBBK i Kliniki w ramach pilotażowego eksperymentu leczniczego są zachęcające. Podczas analiz podawano preparat tego typu w otwartej, tj. niezaślepionej obserwacji bez randomizacji.

Odkrycie może wpłynąć na zmniejszenie liczby amputacji kończyn w wyniku ZSC

Zespół stopy cukrzycowej (ZSC) jest powikłaniem cukrzycy, które rozwija się zazwyczaj w wyniku utrzymujących się wysokich cukrów we krwi. Schorzenie objawia się trudno gojącymi się ranami i owrzodzeniami w obrębie stopy, a także dolegliwościami bólowymi, drętwieniem i zniekształceniem stóp. ZSC może wystąpić we wszystkich typach cukrzycy. Ryzyko wystąpienia zespołu stopy cukrzycowej zwiększa neuropatia, nadciśnienie tętnicze, a także podwyższony wskaźnik masy ciała. Czynniki te obserwowane są u nawet 50 proc. chorych w starszym wieku. Eksperci WUM przytaczają badania, z których wynika, że w grupie chorych na cukrzycę typu 2. w ciągu ich życia owrzodzenie pojawi się u 25 proc. osób, a w ciągu roku – u 2 proc.

Opieka nad pacjentem z ZSC wymaga sprawnego działania multidyscyplinarnego zespołu, złożonego z doświadczonych diabetologów, chirurgów, ortopedów, radiologów interwencyjnych, pielęgniarek i fizjoterapeutów. Niejednokrotnie, pomimo podejmowanych wysiłków, leczenie kończy się niepowodzeniem, wymagającym amputacji kończyny. Szacuje się, że w krajach rozwiniętych ZSC zajmuje pierwsze miejsce wśród powodów nieurazowych amputacji kończyn dolnych. Na tle 31 krajów europejskich, Polska plasuje się na 10 miejscu – podkreślają badacze WUM.

W Polsce, w 2015 r., przeprowadzono 1 795 amputacji kończyny w wyniku powikłań cukrzycy. Wdrożenie leczenia na wczesnym etapie rozwoju ZSC mogłoby zapobiec amputacjom. Dlatego, jak wskazują eksperci, tak istotne jest opracowanie skutecznego sposobu leczenia pacjentów z tym schorzeniem, by przyspieszyć gojenie się ran, a także zredukować powikłania infekcyjne.

Źródło: wum.edu.pl

 

Przeczytaj także: Ocena budowy i funkcji stóp – dlaczego jest kluczowa w profilaktyce zespołu stopy cukrzycowej?

Biblioteka Faktów

Przeczytaj bezpłatnie pokrewny artykuł w czasopiśmie „Forum Zakażeń”:

Charakterystyka i zasady postępowania w przypadku infekcji stopy cukrzycowej

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